Hierarchical dynamics in allostery following ATP hydrolysis monitored by single molecule FRET measurements and MD simulations

We report on a study that combines advanced fluorescence methods with molecular dynamics (MD) simulations to cover timescales from nanoseconds to milliseconds for a large protein. This allows us to delineate how ATP hydrolysis in a protein causes allosteric changes at a distant protein binding site,...

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Detalles Bibliográficos
Autores principales: Wolf, Steffen, Sohmen, Benedikt, Hellenkamp, Björn, Thurn, Johann, Stock, Gerhard, Hugel, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179424/
https://www.ncbi.nlm.nih.gov/pubmed/34164105
http://dx.doi.org/10.1039/d0sc06134d

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