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Albumin-mediated alteration of plasma zinc speciation by fatty acids modulates blood clotting in type-2 diabetes

Zn(2+) is an essential regulator of coagulation and is released from activated platelets. In plasma, the free Zn(2+) concentration is fine-tuned through buffering by human serum albumin (HSA). Importantly, the ability of HSA to bind/buffer Zn(2+) is compromised by co-transported non-esterified fatty...

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Detalles Bibliográficos
Autores principales:	Sobczak, Amélie I. S., Katundu, Kondwani G. H., Phoenix, Fladia A., Khazaipoul, Siavash, Yu, Ruitao, Lampiao, Fanuel, Stefanowicz, Fiona, Blindauer, Claudia A., Pitt, Samantha J., Smith, Terry K., Ajjan, Ramzi A., Stewart, Alan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179462/ https://www.ncbi.nlm.nih.gov/pubmed/34163679 http://dx.doi.org/10.1039/d0sc06605b

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