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Fluorescent small organic probes for biosensing

Small-molecule based fluorescent probes are increasingly important for the detection and imaging of biological signaling molecules due to their simplicity, high selectivity and sensitivity, whilst being non-invasive, and suitable for real-time analysis of living systems. With this perspective we hig...

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Detalles Bibliográficos
Autores principales: Tian, Xue, Murfin, Lloyd C., Wu, Luling, Lewis, Simon E., James, Tony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179477/
https://www.ncbi.nlm.nih.gov/pubmed/34163615
http://dx.doi.org/10.1039/d0sc06928k
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author Tian, Xue
Murfin, Lloyd C.
Wu, Luling
Lewis, Simon E.
James, Tony D.
author_facet Tian, Xue
Murfin, Lloyd C.
Wu, Luling
Lewis, Simon E.
James, Tony D.
author_sort Tian, Xue
collection PubMed
description Small-molecule based fluorescent probes are increasingly important for the detection and imaging of biological signaling molecules due to their simplicity, high selectivity and sensitivity, whilst being non-invasive, and suitable for real-time analysis of living systems. With this perspective we highlight sensing mechanisms including Förster resonance energy transfer (FRET), intramolecular charge transfer (ICT), photoinduced electron transfer (PeT), excited state intramolecular proton transfer (ESIPT), aggregation induced emission (AIE) and multiple modality fluorescence approaches including dual/triple sensing mechanisms (DSM or TSM). Throughout the perspective we highlight the remaining challenges and suggest potential directions for development towards improved small-molecule fluorescent probes suitable for biosensing.
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spelling pubmed-81794772021-06-22 Fluorescent small organic probes for biosensing Tian, Xue Murfin, Lloyd C. Wu, Luling Lewis, Simon E. James, Tony D. Chem Sci Chemistry Small-molecule based fluorescent probes are increasingly important for the detection and imaging of biological signaling molecules due to their simplicity, high selectivity and sensitivity, whilst being non-invasive, and suitable for real-time analysis of living systems. With this perspective we highlight sensing mechanisms including Förster resonance energy transfer (FRET), intramolecular charge transfer (ICT), photoinduced electron transfer (PeT), excited state intramolecular proton transfer (ESIPT), aggregation induced emission (AIE) and multiple modality fluorescence approaches including dual/triple sensing mechanisms (DSM or TSM). Throughout the perspective we highlight the remaining challenges and suggest potential directions for development towards improved small-molecule fluorescent probes suitable for biosensing. The Royal Society of Chemistry 2021-01-18 /pmc/articles/PMC8179477/ /pubmed/34163615 http://dx.doi.org/10.1039/d0sc06928k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Tian, Xue
Murfin, Lloyd C.
Wu, Luling
Lewis, Simon E.
James, Tony D.
Fluorescent small organic probes for biosensing
title Fluorescent small organic probes for biosensing
title_full Fluorescent small organic probes for biosensing
title_fullStr Fluorescent small organic probes for biosensing
title_full_unstemmed Fluorescent small organic probes for biosensing
title_short Fluorescent small organic probes for biosensing
title_sort fluorescent small organic probes for biosensing
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179477/
https://www.ncbi.nlm.nih.gov/pubmed/34163615
http://dx.doi.org/10.1039/d0sc06928k
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