Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin

Vasopressin (VP) and oxytocin (OT) are cyclic neuropeptides that regulate fundamental physiological functions via four G protein-coupled receptors, V(1a)R, V(1b)R, V(2)R, and OTR. Ligand development remains challenging for these receptors due to complex structure–activity relationships. Here, we inv...

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Detalles Bibliográficos
Autores principales: Dekan, Zoltan, Kremsmayr, Thomas, Keov, Peter, Godin, Mathilde, Teakle, Ngari, Dürrauer, Leopold, Xiang, Huang, Gharib, Dalia, Bergmayr, Christian, Hellinger, Roland, Gay, Marina, Vilaseca, Marta, Kurzbach, Dennis, Albericio, Fernando, Alewood, Paul F., Gruber, Christian W., Muttenthaler, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179488/
https://www.ncbi.nlm.nih.gov/pubmed/34163676
http://dx.doi.org/10.1039/d0sc05501h

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