Photo-induced copper-catalyzed alkynylation and amination of remote unactivated C(sp(3))-H bonds

A method for remote radical C–H alkynylation and amination of diverse aliphatic alcohols has been developed. The reaction features a copper nucleophile complex formed in situ as a photocatalyst, which reduces the silicon-tethered aliphatic iodide to an alkyl radical to initiate 1,n-hydrogen atom tra...

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Detalles Bibliográficos
Autores principales: Cao, Zhusong, Li, Jianye, Sun, Youwen, Zhang, Hanwen, Mo, Xueling, Cao, Xin, Zhang, Guozhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179574/
https://www.ncbi.nlm.nih.gov/pubmed/34163735
http://dx.doi.org/10.1039/d0sc05883a
Descripción
Sumario:A method for remote radical C–H alkynylation and amination of diverse aliphatic alcohols has been developed. The reaction features a copper nucleophile complex formed in situ as a photocatalyst, which reduces the silicon-tethered aliphatic iodide to an alkyl radical to initiate 1,n-hydrogen atom transfer. Unactivated secondary and tertiary C–H bonds at β, γ, and δ positions can be functionalized in a predictable manner.

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