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Enantioselective hydrogenation of annulated arenes: controlled formation of multiple stereocenters in adjacent rings

We report a method for the enantioselective hydrogenation of annulated arenes using 4H-pyrido[1,2-a]pyrimidinones as substrates. The method selectively generates multiple stereocenters in adjacent rings leading to architecturally complex motifs, which resemble bioactive molecules. The mechanistic st...

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Detalles Bibliográficos
Autores principales:	Wiesenfeldt, Mario P., Moock, Daniel, Paul, Daniel, Glorius, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179591/ https://www.ncbi.nlm.nih.gov/pubmed/34163775 http://dx.doi.org/10.1039/d0sc07099h

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