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Aggregation-free and high stability core–shell polymer nanoparticles with high fullerene loading capacity, variable fullerene type, and compatibility towards biological conditions
Fullerenes have unique structural and electronic properties that make them attractive candidates for diagnostic, therapeutic, and theranostic applications. However, their poor water solubility remains a limiting factor in realizing their full biomedical potential. Here, we present an approach based...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179596/ https://www.ncbi.nlm.nih.gov/pubmed/34163742 http://dx.doi.org/10.1039/d1sc00602a |
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author | Eom, Taejun Barát, Viktor Khan, Anzar Stuparu, Mihaiela C. |
author_facet | Eom, Taejun Barát, Viktor Khan, Anzar Stuparu, Mihaiela C. |
author_sort | Eom, Taejun |
collection | PubMed |
description | Fullerenes have unique structural and electronic properties that make them attractive candidates for diagnostic, therapeutic, and theranostic applications. However, their poor water solubility remains a limiting factor in realizing their full biomedical potential. Here, we present an approach based on a combination of supramolecular and covalent chemistry to access well-defined fullerene-containing polymer nanoparticles with a core–shell structure. In this approach, solvophobic forces and aromatic interactions first come into play to afford a micellar structure with a poly(ethylene glycol) shell and a corannulene-based fullerene-rich core. Covalent stabilization of the supramolecular assembly then affords core-crosslinked polymer nanoparticles. The shell makes these nanoparticles biocompatible and allows them to be dried to a solid and redispersed in water without inducing interparticle aggregation. The core allows a high content of different fullerene types to be encapsulated. Finally, covalent stabilization endows nanostructures with stability against changing environmental conditions. |
format | Online Article Text |
id | pubmed-8179596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-81795962021-06-22 Aggregation-free and high stability core–shell polymer nanoparticles with high fullerene loading capacity, variable fullerene type, and compatibility towards biological conditions Eom, Taejun Barát, Viktor Khan, Anzar Stuparu, Mihaiela C. Chem Sci Chemistry Fullerenes have unique structural and electronic properties that make them attractive candidates for diagnostic, therapeutic, and theranostic applications. However, their poor water solubility remains a limiting factor in realizing their full biomedical potential. Here, we present an approach based on a combination of supramolecular and covalent chemistry to access well-defined fullerene-containing polymer nanoparticles with a core–shell structure. In this approach, solvophobic forces and aromatic interactions first come into play to afford a micellar structure with a poly(ethylene glycol) shell and a corannulene-based fullerene-rich core. Covalent stabilization of the supramolecular assembly then affords core-crosslinked polymer nanoparticles. The shell makes these nanoparticles biocompatible and allows them to be dried to a solid and redispersed in water without inducing interparticle aggregation. The core allows a high content of different fullerene types to be encapsulated. Finally, covalent stabilization endows nanostructures with stability against changing environmental conditions. The Royal Society of Chemistry 2021-02-24 /pmc/articles/PMC8179596/ /pubmed/34163742 http://dx.doi.org/10.1039/d1sc00602a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Eom, Taejun Barát, Viktor Khan, Anzar Stuparu, Mihaiela C. Aggregation-free and high stability core–shell polymer nanoparticles with high fullerene loading capacity, variable fullerene type, and compatibility towards biological conditions |
title | Aggregation-free and high stability core–shell polymer nanoparticles with high fullerene loading capacity, variable fullerene type, and compatibility towards biological conditions |
title_full | Aggregation-free and high stability core–shell polymer nanoparticles with high fullerene loading capacity, variable fullerene type, and compatibility towards biological conditions |
title_fullStr | Aggregation-free and high stability core–shell polymer nanoparticles with high fullerene loading capacity, variable fullerene type, and compatibility towards biological conditions |
title_full_unstemmed | Aggregation-free and high stability core–shell polymer nanoparticles with high fullerene loading capacity, variable fullerene type, and compatibility towards biological conditions |
title_short | Aggregation-free and high stability core–shell polymer nanoparticles with high fullerene loading capacity, variable fullerene type, and compatibility towards biological conditions |
title_sort | aggregation-free and high stability core–shell polymer nanoparticles with high fullerene loading capacity, variable fullerene type, and compatibility towards biological conditions |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179596/ https://www.ncbi.nlm.nih.gov/pubmed/34163742 http://dx.doi.org/10.1039/d1sc00602a |
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