Nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides

We report an asymmetric Ni-catalyzed reductive cross-coupling of aryl/heteroaryl halides with racemic α-chlorosulfones to afford enantioenriched sulfones. The reaction tolerates a variety of functional groups under mild reaction conditions, which complements the current methods. The utility of this...

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Detalles Bibliográficos
Autores principales: Sun, Deli, Ma, Guobin, Zhao, Xinluo, Lei, Chuanhu, Gong, Hegui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179603/
https://www.ncbi.nlm.nih.gov/pubmed/34168777
http://dx.doi.org/10.1039/d1sc00283j
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author Sun, Deli
Ma, Guobin
Zhao, Xinluo
Lei, Chuanhu
Gong, Hegui
author_facet Sun, Deli
Ma, Guobin
Zhao, Xinluo
Lei, Chuanhu
Gong, Hegui
author_sort Sun, Deli
collection PubMed
description We report an asymmetric Ni-catalyzed reductive cross-coupling of aryl/heteroaryl halides with racemic α-chlorosulfones to afford enantioenriched sulfones. The reaction tolerates a variety of functional groups under mild reaction conditions, which complements the current methods. The utility of this work was demonstrated by facile late-stage functionalization of commercial drugs.
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spelling pubmed-81796032021-06-23 Nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides Sun, Deli Ma, Guobin Zhao, Xinluo Lei, Chuanhu Gong, Hegui Chem Sci Chemistry We report an asymmetric Ni-catalyzed reductive cross-coupling of aryl/heteroaryl halides with racemic α-chlorosulfones to afford enantioenriched sulfones. The reaction tolerates a variety of functional groups under mild reaction conditions, which complements the current methods. The utility of this work was demonstrated by facile late-stage functionalization of commercial drugs. The Royal Society of Chemistry 2021-02-19 /pmc/articles/PMC8179603/ /pubmed/34168777 http://dx.doi.org/10.1039/d1sc00283j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Sun, Deli
Ma, Guobin
Zhao, Xinluo
Lei, Chuanhu
Gong, Hegui
Nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides
title Nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides
title_full Nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides
title_fullStr Nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides
title_full_unstemmed Nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides
title_short Nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides
title_sort nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179603/
https://www.ncbi.nlm.nih.gov/pubmed/34168777
http://dx.doi.org/10.1039/d1sc00283j
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AT maguobin nickelcatalyzedasymmetricreductivearylationofachlorosulfoneswitharylhalides
AT zhaoxinluo nickelcatalyzedasymmetricreductivearylationofachlorosulfoneswitharylhalides
AT leichuanhu nickelcatalyzedasymmetricreductivearylationofachlorosulfoneswitharylhalides
AT gonghegui nickelcatalyzedasymmetricreductivearylationofachlorosulfoneswitharylhalides

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