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Single-molecule analysis of interaction between p53TAD and MDM2 using aerolysin nanopores

Protein–protein interactions (PPIs) are regarded as important, but undruggable targets. Intrinsically disordered p53 transactivation domain (p53TAD) mediates PPI with mouse double minute 2 (MDM2), which is an attractive anticancer target for therapeutic intervention. Here, using aerolysin nanopores,...

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Detalles Bibliográficos
Autores principales:	Oh, Sohee, Lee, Mi-Kyung, Chi, Seung-Wook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179679/ https://www.ncbi.nlm.nih.gov/pubmed/34168813 http://dx.doi.org/10.1039/d1sc00386k

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