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Linguistic-Cognitive Outcomes in Children with Acute Lymphoid Leukemia: An Exploratory Study

BACKGROUND: Acute lymphoid leukemia (ALL) is the most prevalent cancer of childhood. Impairment in linguistic and memory skills is a possible late sequela in cancer survivors that can limit their quality of life and the overall performance of the individual in society. There is evidence that survivo...

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Autores principales: Miranda Pereira, Michelle, Befi-Lopes, Debora Maria, Soares, Aparecido José Couto, Sassi, Fernanda Chiarion, de Andrade, Claudia Regina Furquim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179787/
https://www.ncbi.nlm.nih.gov/pubmed/34103929
http://dx.doi.org/10.2147/JMDH.S313795
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author Miranda Pereira, Michelle
Befi-Lopes, Debora Maria
Soares, Aparecido José Couto
Sassi, Fernanda Chiarion
de Andrade, Claudia Regina Furquim
author_facet Miranda Pereira, Michelle
Befi-Lopes, Debora Maria
Soares, Aparecido José Couto
Sassi, Fernanda Chiarion
de Andrade, Claudia Regina Furquim
author_sort Miranda Pereira, Michelle
collection PubMed
description BACKGROUND: Acute lymphoid leukemia (ALL) is the most prevalent cancer of childhood. Impairment in linguistic and memory skills is a possible late sequela in cancer survivors that can limit their quality of life and the overall performance of the individual in society. There is evidence that survivors of ALL treated exclusively with chemotherapy demonstrate significant differences in long-term linguistic and memory functions and also changes in neuroanatomical integrity. However, most studies described do not count on a speech-language pathologist in their team, which we consider important to discuss. Thus, the objective of the present study was to assess memory and vocabulary skills in the pediatric population diagnosed with acute lymphoid leukemia during chemotherapy treatment. MATERIALS AND METHODS: An observational cohort study was conducted over a 1.8-year period. Participants of this research were children diagnosed with ALL. All participants were assessed on their linguistic-cognitive skills (ie, vocabulary, short-term memory and lexical access). All data underwent statistical analyses. RESULTS: The results of the current study found no major significant difference in the linguistic-cognitive performance of children with ALL and their healthy controls. Regarding the linguistic variables, we believe that there should be a differentiation between the effects of the drugs and the effects of social communication skills on performance. CONCLUSION: This first characterization of the linguistic-cognitive abilities of children with ALL did not identify differences between these children and their healthy peers, although we were able to identify variables regarding the multidisciplinary team and social communication that should be considered in future studies.
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spelling pubmed-81797872021-06-07 Linguistic-Cognitive Outcomes in Children with Acute Lymphoid Leukemia: An Exploratory Study Miranda Pereira, Michelle Befi-Lopes, Debora Maria Soares, Aparecido José Couto Sassi, Fernanda Chiarion de Andrade, Claudia Regina Furquim J Multidiscip Healthc Original Research BACKGROUND: Acute lymphoid leukemia (ALL) is the most prevalent cancer of childhood. Impairment in linguistic and memory skills is a possible late sequela in cancer survivors that can limit their quality of life and the overall performance of the individual in society. There is evidence that survivors of ALL treated exclusively with chemotherapy demonstrate significant differences in long-term linguistic and memory functions and also changes in neuroanatomical integrity. However, most studies described do not count on a speech-language pathologist in their team, which we consider important to discuss. Thus, the objective of the present study was to assess memory and vocabulary skills in the pediatric population diagnosed with acute lymphoid leukemia during chemotherapy treatment. MATERIALS AND METHODS: An observational cohort study was conducted over a 1.8-year period. Participants of this research were children diagnosed with ALL. All participants were assessed on their linguistic-cognitive skills (ie, vocabulary, short-term memory and lexical access). All data underwent statistical analyses. RESULTS: The results of the current study found no major significant difference in the linguistic-cognitive performance of children with ALL and their healthy controls. Regarding the linguistic variables, we believe that there should be a differentiation between the effects of the drugs and the effects of social communication skills on performance. CONCLUSION: This first characterization of the linguistic-cognitive abilities of children with ALL did not identify differences between these children and their healthy peers, although we were able to identify variables regarding the multidisciplinary team and social communication that should be considered in future studies. Dove 2021-06-01 /pmc/articles/PMC8179787/ /pubmed/34103929 http://dx.doi.org/10.2147/JMDH.S313795 Text en © 2021 Miranda Pereira et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Miranda Pereira, Michelle
Befi-Lopes, Debora Maria
Soares, Aparecido José Couto
Sassi, Fernanda Chiarion
de Andrade, Claudia Regina Furquim
Linguistic-Cognitive Outcomes in Children with Acute Lymphoid Leukemia: An Exploratory Study
title Linguistic-Cognitive Outcomes in Children with Acute Lymphoid Leukemia: An Exploratory Study
title_full Linguistic-Cognitive Outcomes in Children with Acute Lymphoid Leukemia: An Exploratory Study
title_fullStr Linguistic-Cognitive Outcomes in Children with Acute Lymphoid Leukemia: An Exploratory Study
title_full_unstemmed Linguistic-Cognitive Outcomes in Children with Acute Lymphoid Leukemia: An Exploratory Study
title_short Linguistic-Cognitive Outcomes in Children with Acute Lymphoid Leukemia: An Exploratory Study
title_sort linguistic-cognitive outcomes in children with acute lymphoid leukemia: an exploratory study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179787/
https://www.ncbi.nlm.nih.gov/pubmed/34103929
http://dx.doi.org/10.2147/JMDH.S313795
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