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Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature
OBJECTIVE: To review the mechanisms of endometriosis development, including those related to epigenetic mutations, cellular dysregulation, inflammatory processes, and oxidative stress. METHODS: A systematic literature review regarding current aspects of endometriosis etiology, genesis and developmen...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179825/ https://www.ncbi.nlm.nih.gov/pubmed/34104002 http://dx.doi.org/10.2147/IJWH.S306135 |
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author | Mikhaleva, Lyudmila M Radzinsky, Victor E Orazov, Mekan R Khovanskaya, Tatyana N Sorokina, Anastasia V Mikhalev, Sergey A Volkova, Snezhana V Shustova, Victoria B Sinelnikov, Mikhail Y |
author_facet | Mikhaleva, Lyudmila M Radzinsky, Victor E Orazov, Mekan R Khovanskaya, Tatyana N Sorokina, Anastasia V Mikhalev, Sergey A Volkova, Snezhana V Shustova, Victoria B Sinelnikov, Mikhail Y |
author_sort | Mikhaleva, Lyudmila M |
collection | PubMed |
description | OBJECTIVE: To review the mechanisms of endometriosis development, including those related to epigenetic mutations, cellular dysregulation, inflammatory processes, and oxidative stress. METHODS: A systematic literature review regarding current aspects of endometriosis etiology, genesis and development was performed using the PubMed, Google Scholar, and eLibrary databases. Keywords included endometriosis, etiology, development, genesis, associations and mechanisms. A multilingual search was performed. RESULTS: Several mechanisms underline the pathophysiological pathways for endometriosis development. Epigenetic mutations, external and internal influences, and chronic conditions have a significant impact on endometriosis development, survival and regulation. Several historically valid theories on endometriosis development were discussed, as well as updated findings. CONCLUSION: Despite recent advances, fundamental problems in understanding endometriosis remain unresolved. The identification of unknown circulating epithelial progenitors or stem cells that are responsible for epithelial growth in both the endometrium and endometriotic foci seems to be the next step in solving these questions. |
format | Online Article Text |
id | pubmed-8179825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-81798252021-06-07 Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature Mikhaleva, Lyudmila M Radzinsky, Victor E Orazov, Mekan R Khovanskaya, Tatyana N Sorokina, Anastasia V Mikhalev, Sergey A Volkova, Snezhana V Shustova, Victoria B Sinelnikov, Mikhail Y Int J Womens Health Review OBJECTIVE: To review the mechanisms of endometriosis development, including those related to epigenetic mutations, cellular dysregulation, inflammatory processes, and oxidative stress. METHODS: A systematic literature review regarding current aspects of endometriosis etiology, genesis and development was performed using the PubMed, Google Scholar, and eLibrary databases. Keywords included endometriosis, etiology, development, genesis, associations and mechanisms. A multilingual search was performed. RESULTS: Several mechanisms underline the pathophysiological pathways for endometriosis development. Epigenetic mutations, external and internal influences, and chronic conditions have a significant impact on endometriosis development, survival and regulation. Several historically valid theories on endometriosis development were discussed, as well as updated findings. CONCLUSION: Despite recent advances, fundamental problems in understanding endometriosis remain unresolved. The identification of unknown circulating epithelial progenitors or stem cells that are responsible for epithelial growth in both the endometrium and endometriotic foci seems to be the next step in solving these questions. Dove 2021-06-01 /pmc/articles/PMC8179825/ /pubmed/34104002 http://dx.doi.org/10.2147/IJWH.S306135 Text en © 2021 Mikhaleva et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Mikhaleva, Lyudmila M Radzinsky, Victor E Orazov, Mekan R Khovanskaya, Tatyana N Sorokina, Anastasia V Mikhalev, Sergey A Volkova, Snezhana V Shustova, Victoria B Sinelnikov, Mikhail Y Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature |
title | Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature |
title_full | Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature |
title_fullStr | Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature |
title_full_unstemmed | Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature |
title_short | Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature |
title_sort | current knowledge on endometriosis etiology: a systematic review of literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179825/ https://www.ncbi.nlm.nih.gov/pubmed/34104002 http://dx.doi.org/10.2147/IJWH.S306135 |
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