Variances in BCG protection against COVID-19 mortality: A global assessment

The BCG vaccine is known to impart nonspecific immunological benefits alongside conferring protection to tuberculosis in endemic regions. It is also known to protect against bladder cancer and other respiratory tract infections. During the coronavirus disease 2019 (COVID-19) pandemic, the BCG vaccin...

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Detalles Bibliográficos
Autores principales: Sarfraz, Zouina, Sarfraz, Azza, Pandav, Krunal, Singh Makkar, Sarabjot, Hasan Siddiqui, Saman, Patel, Gaurav, Platero-Portillo, Tania, Singh, Bishnu Mohan, Maideen, Mohamed Iburahim Haja, Sarvepalli, Deepika, Sarfraz, Muzna, Cardona-Guzman, Jose, Sanchez-Gonzalez, Marcos A., Cherrez-Ojeda, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179855/
https://www.ncbi.nlm.nih.gov/pubmed/34124396
http://dx.doi.org/10.1016/j.jctube.2021.100249
Descripción
Sumario:The BCG vaccine is known to impart nonspecific immunological benefits alongside conferring protection to tuberculosis in endemic regions. It is also known to protect against bladder cancer and other respiratory tract infections. During the coronavirus disease 2019 (COVID-19) pandemic, the BCG vaccine has gained attention due to its role in conferring protective immunity. We demonstrate the potential immunological protective mechanisms that play a role against COVID-19. We conduct a global assessment of the countries that have the highest and lowest mortality rates determined by an a priori methodology. Lastly, we discuss the potential limitations of incorporating BCG vaccines as potential strategies against COVID-19 and provide recommendations regarding their use in ongoing and future epidemics.

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