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Significance of liver resection for intermediate stage hepatocellular carcinoma according to subclassification

BACKGROUND: Patients diagnosed with Barcelona Clinic Liver Cancer (BCLC) intermediate stage hepatocellular carcinoma (HCC) encompass a broad clinical population. Kinki criteria subclassifications have been proposed to better predict prognoses and determine appropriate treatment strategies for these...

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Autores principales: Yamamoto, Masateru, Kobayashi, Tsuyoshi, Hashimoto, Masakazu, Kuroda, Shintaro, Kawaoka, Tomokazu, Aikata, Hiroshi, Chayama, Kazuaki, Ohdan, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180017/
https://www.ncbi.nlm.nih.gov/pubmed/34090354
http://dx.doi.org/10.1186/s12885-021-08421-3
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author Yamamoto, Masateru
Kobayashi, Tsuyoshi
Hashimoto, Masakazu
Kuroda, Shintaro
Kawaoka, Tomokazu
Aikata, Hiroshi
Chayama, Kazuaki
Ohdan, Hideki
author_facet Yamamoto, Masateru
Kobayashi, Tsuyoshi
Hashimoto, Masakazu
Kuroda, Shintaro
Kawaoka, Tomokazu
Aikata, Hiroshi
Chayama, Kazuaki
Ohdan, Hideki
author_sort Yamamoto, Masateru
collection PubMed
description BACKGROUND: Patients diagnosed with Barcelona Clinic Liver Cancer (BCLC) intermediate stage hepatocellular carcinoma (HCC) encompass a broad clinical population. Kinki criteria subclassifications have been proposed to better predict prognoses and determine appropriate treatment strategies for these patients. This study validated the prognostic significance within the Kinki criteria substages and analyzed the role of liver resection in patients with intermediate stage HCC. METHODS: Patients with intermediate stage HCC (n = 378) were retrospectively subclassified according to the Kinki criteria (B1, n = 123; B2, n = 225; and B3, n = 30). We analyzed the overall survival (OS) and treatment methods. RESULTS: The OS was significantly different between adjacent substages. Patients in substage B1 who underwent liver resection had a significantly better prognosis than those who did not, even after propensity score matching (PSM). Patients in substage B2 who underwent liver resection had a significantly better prognosis than those who did not; however, there was no difference after PSM. There was no difference in prognosis based on treatments among patients in substage B3. CONCLUSIONS: The Kinki criteria clearly stratify patients with intermediate stage HCC by prognosis. For substage B1 HCC patients, liver resection provides a better prognosis than other treatment modalities. In patients with substage B2 and B3, an alternative approach is required. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08421-3.
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spelling pubmed-81800172021-06-07 Significance of liver resection for intermediate stage hepatocellular carcinoma according to subclassification Yamamoto, Masateru Kobayashi, Tsuyoshi Hashimoto, Masakazu Kuroda, Shintaro Kawaoka, Tomokazu Aikata, Hiroshi Chayama, Kazuaki Ohdan, Hideki BMC Cancer Research BACKGROUND: Patients diagnosed with Barcelona Clinic Liver Cancer (BCLC) intermediate stage hepatocellular carcinoma (HCC) encompass a broad clinical population. Kinki criteria subclassifications have been proposed to better predict prognoses and determine appropriate treatment strategies for these patients. This study validated the prognostic significance within the Kinki criteria substages and analyzed the role of liver resection in patients with intermediate stage HCC. METHODS: Patients with intermediate stage HCC (n = 378) were retrospectively subclassified according to the Kinki criteria (B1, n = 123; B2, n = 225; and B3, n = 30). We analyzed the overall survival (OS) and treatment methods. RESULTS: The OS was significantly different between adjacent substages. Patients in substage B1 who underwent liver resection had a significantly better prognosis than those who did not, even after propensity score matching (PSM). Patients in substage B2 who underwent liver resection had a significantly better prognosis than those who did not; however, there was no difference after PSM. There was no difference in prognosis based on treatments among patients in substage B3. CONCLUSIONS: The Kinki criteria clearly stratify patients with intermediate stage HCC by prognosis. For substage B1 HCC patients, liver resection provides a better prognosis than other treatment modalities. In patients with substage B2 and B3, an alternative approach is required. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-08421-3. BioMed Central 2021-06-05 /pmc/articles/PMC8180017/ /pubmed/34090354 http://dx.doi.org/10.1186/s12885-021-08421-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yamamoto, Masateru
Kobayashi, Tsuyoshi
Hashimoto, Masakazu
Kuroda, Shintaro
Kawaoka, Tomokazu
Aikata, Hiroshi
Chayama, Kazuaki
Ohdan, Hideki
Significance of liver resection for intermediate stage hepatocellular carcinoma according to subclassification
title Significance of liver resection for intermediate stage hepatocellular carcinoma according to subclassification
title_full Significance of liver resection for intermediate stage hepatocellular carcinoma according to subclassification
title_fullStr Significance of liver resection for intermediate stage hepatocellular carcinoma according to subclassification
title_full_unstemmed Significance of liver resection for intermediate stage hepatocellular carcinoma according to subclassification
title_short Significance of liver resection for intermediate stage hepatocellular carcinoma according to subclassification
title_sort significance of liver resection for intermediate stage hepatocellular carcinoma according to subclassification
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180017/
https://www.ncbi.nlm.nih.gov/pubmed/34090354
http://dx.doi.org/10.1186/s12885-021-08421-3
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