Optimising NK cell metabolism to increase the efficacy of cancer immunotherapy

Immunotherapy has ushered in an exciting new era for cancer treatment. The recent discovery and success of immune checkpoint blockade and chimeric antigen receptor (CAR) T cell adoptive cell transfer has raised interest in using other immune cells, including Natural Killer (NK) cells, which might ov...

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Detalles Bibliográficos
Autores principales: Choi, Chloe, Finlay, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180160/
https://www.ncbi.nlm.nih.gov/pubmed/34090499
http://dx.doi.org/10.1186/s13287-021-02377-8
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author Choi, Chloe
Finlay, David K.
author_facet Choi, Chloe
Finlay, David K.
author_sort Choi, Chloe
collection PubMed
description Immunotherapy has ushered in an exciting new era for cancer treatment. The recent discovery and success of immune checkpoint blockade and chimeric antigen receptor (CAR) T cell adoptive cell transfer has raised interest in using other immune cells, including Natural Killer (NK) cells, which might overcome some limitations with CAR T cell therapy. In this review article, we discuss the evidence that cellular metabolism is crucial for NK cell effector function. Additionally, potential strategies to optimise the metabolism of therapeutic NK cells for improved function within the metabolically adverse tumour microenvironment will be explored.
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spelling pubmed-81801602021-06-07 Optimising NK cell metabolism to increase the efficacy of cancer immunotherapy Choi, Chloe Finlay, David K. Stem Cell Res Ther Review Immunotherapy has ushered in an exciting new era for cancer treatment. The recent discovery and success of immune checkpoint blockade and chimeric antigen receptor (CAR) T cell adoptive cell transfer has raised interest in using other immune cells, including Natural Killer (NK) cells, which might overcome some limitations with CAR T cell therapy. In this review article, we discuss the evidence that cellular metabolism is crucial for NK cell effector function. Additionally, potential strategies to optimise the metabolism of therapeutic NK cells for improved function within the metabolically adverse tumour microenvironment will be explored. BioMed Central 2021-06-05 /pmc/articles/PMC8180160/ /pubmed/34090499 http://dx.doi.org/10.1186/s13287-021-02377-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Choi, Chloe
Finlay, David K.
Optimising NK cell metabolism to increase the efficacy of cancer immunotherapy
title Optimising NK cell metabolism to increase the efficacy of cancer immunotherapy
title_full Optimising NK cell metabolism to increase the efficacy of cancer immunotherapy
title_fullStr Optimising NK cell metabolism to increase the efficacy of cancer immunotherapy
title_full_unstemmed Optimising NK cell metabolism to increase the efficacy of cancer immunotherapy
title_short Optimising NK cell metabolism to increase the efficacy of cancer immunotherapy
title_sort optimising nk cell metabolism to increase the efficacy of cancer immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180160/
https://www.ncbi.nlm.nih.gov/pubmed/34090499
http://dx.doi.org/10.1186/s13287-021-02377-8
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