Differential chromatin accessibility landscape of gain-of-function mutant p53 tumours

BACKGROUND: Mutations in TP53 not only affect its tumour suppressor activity but also exerts oncogenic gain-of-function activity. While the genome-wide mutant p53 binding sites have been identified in cancer cell lines, the chromatin accessibility landscape driven by mutant p53 in primary tumours is...

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Detalles Bibliográficos
Autores principales: Dhaka, Bhavya, Sabarinathan, Radhakrishnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180165/
https://www.ncbi.nlm.nih.gov/pubmed/34090364
http://dx.doi.org/10.1186/s12885-021-08362-x

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