Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF

Nephron endowment, defined during the fetal period, dictates renal and related cardiovascular health throughout life. We show here that, despite its negative effects on kidney growth, genetic increase of GDNF prolongs the nephrogenic program beyond its normal cessation. Multi-stage mechanistic analy...

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Detalles Bibliográficos
Autores principales: Li, Hao, Kurtzeborn, Kristen, Kupari, Jussi, Gui, Yujuan, Siefker, Edward, Lu, Benson, Mätlik, Kärt, Olfat, Soophie, Montaño-Rodríguez, Ana R., Huh, Sung-Ho, Costantini, Franklin, Andressoo, Jaan-Olle, Kuure, Satu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180252/
https://www.ncbi.nlm.nih.gov/pubmed/34032268
http://dx.doi.org/10.1242/dev.197475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180252/
https://www.ncbi.nlm.nih.gov/pubmed/34032268
http://dx.doi.org/10.1242/dev.197475

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