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FGF signaling acts on different levels of mesoderm development within Spiralia
FGF signaling is involved in mesoderm induction in members of deuterostomes (e.g. tunicates, hemichordates), but not in flies and nematodes, in which it has a role in mesoderm patterning and migration. However, we need comparable studies in other protostome taxa in order to decipher whether this mes...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180254/ https://www.ncbi.nlm.nih.gov/pubmed/33999997 http://dx.doi.org/10.1242/dev.196089 |
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author | Andrikou, Carmen Hejnol, Andreas |
author_facet | Andrikou, Carmen Hejnol, Andreas |
author_sort | Andrikou, Carmen |
collection | PubMed |
description | FGF signaling is involved in mesoderm induction in members of deuterostomes (e.g. tunicates, hemichordates), but not in flies and nematodes, in which it has a role in mesoderm patterning and migration. However, we need comparable studies in other protostome taxa in order to decipher whether this mesoderm-inducing function of FGF extends beyond the lineage of deuterostomes. Here, we investigated the role of FGF signaling in mesoderm development in three species of lophophorates, a clade within the protostome group Spiralia. Our gene expression analyses show that the mesodermal molecular patterning is conserved between brachiopods and phoronids, but the spatial and temporal recruitment of transcription factors differs significantly. Moreover, the use of the inhibitor SU5402 demonstrates that FGF signaling is involved in different steps of mesoderm development, as well as in morphogenetic movements of gastrulation and axial elongation. Our findings suggest that the mesoderm-inducing role of FGF extends beyond the group of deuterostomes. |
format | Online Article Text |
id | pubmed-8180254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Company of Biologists Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-81802542021-06-08 FGF signaling acts on different levels of mesoderm development within Spiralia Andrikou, Carmen Hejnol, Andreas Development Research Article FGF signaling is involved in mesoderm induction in members of deuterostomes (e.g. tunicates, hemichordates), but not in flies and nematodes, in which it has a role in mesoderm patterning and migration. However, we need comparable studies in other protostome taxa in order to decipher whether this mesoderm-inducing function of FGF extends beyond the lineage of deuterostomes. Here, we investigated the role of FGF signaling in mesoderm development in three species of lophophorates, a clade within the protostome group Spiralia. Our gene expression analyses show that the mesodermal molecular patterning is conserved between brachiopods and phoronids, but the spatial and temporal recruitment of transcription factors differs significantly. Moreover, the use of the inhibitor SU5402 demonstrates that FGF signaling is involved in different steps of mesoderm development, as well as in morphogenetic movements of gastrulation and axial elongation. Our findings suggest that the mesoderm-inducing role of FGF extends beyond the group of deuterostomes. The Company of Biologists Ltd 2021-05-17 /pmc/articles/PMC8180254/ /pubmed/33999997 http://dx.doi.org/10.1242/dev.196089 Text en © 2021. Published by The Company of Biologists Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Research Article Andrikou, Carmen Hejnol, Andreas FGF signaling acts on different levels of mesoderm development within Spiralia |
title | FGF signaling acts on different levels of mesoderm development within Spiralia |
title_full | FGF signaling acts on different levels of mesoderm development within Spiralia |
title_fullStr | FGF signaling acts on different levels of mesoderm development within Spiralia |
title_full_unstemmed | FGF signaling acts on different levels of mesoderm development within Spiralia |
title_short | FGF signaling acts on different levels of mesoderm development within Spiralia |
title_sort | fgf signaling acts on different levels of mesoderm development within spiralia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180254/ https://www.ncbi.nlm.nih.gov/pubmed/33999997 http://dx.doi.org/10.1242/dev.196089 |
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