The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models

The search for successful therapies of infections with the coronavirus SARS-CoV-2 is ongoing. We tested inhibition of host cell nucleotide synthesis as a promising strategy to decrease the replication of SARS-CoV-2-RNA, thus diminishing the formation of virus progeny. Methotrexate (MTX) is an establ...

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Detalles Bibliográficos
Autores principales: Stegmann, Kim M., Dickmanns, Antje, Gerber, Sabrina, Nikolova, Vella, Klemke, Luisa, Manzini, Valentina, Schlösser, Denise, Bierwirth, Cathrin, Freund, Julia, Sitte, Maren, Lugert, Raimond, Salinas, Gabriela, Meister, Toni Luise, Pfaender, Stephanie, Görlich, Dirk, Wollnik, Bernd, Groß, Uwe, Dobbelstein, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180352/
https://www.ncbi.nlm.nih.gov/pubmed/34090962
http://dx.doi.org/10.1016/j.virusres.2021.198469

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