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Immediate Analgesic Effect of Acupuncture in Patients With Primary Dysmenorrhea: A fMRI Study

Primary dysmenorrhea (PDM) is a common gynecological disease characterized by lower abdominal pain. Acupuncture is considered a good alternative therapy for PDM. However, the central mechanism of the analgesic effect of acupuncture is largely unknown. In this study, eligible patients were randomized...

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Autores principales: Wang, Yanan, Xu, Jing, Zhang, Qing, Zhang, Qi, Yang, Ya, Wei, Wei, Guo, Xiaoli, Liang, Fanrong, Yu, Siyi, Yang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180846/
https://www.ncbi.nlm.nih.gov/pubmed/34108856
http://dx.doi.org/10.3389/fnins.2021.647667
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author Wang, Yanan
Xu, Jing
Zhang, Qing
Zhang, Qi
Yang, Ya
Wei, Wei
Guo, Xiaoli
Liang, Fanrong
Yu, Siyi
Yang, Jie
author_facet Wang, Yanan
Xu, Jing
Zhang, Qing
Zhang, Qi
Yang, Ya
Wei, Wei
Guo, Xiaoli
Liang, Fanrong
Yu, Siyi
Yang, Jie
author_sort Wang, Yanan
collection PubMed
description Primary dysmenorrhea (PDM) is a common gynecological disease characterized by lower abdominal pain. Acupuncture is considered a good alternative therapy for PDM. However, the central mechanism of the analgesic effect of acupuncture is largely unknown. In this study, eligible patients were randomized into the real and sham acupuncture groups using a computer-generated, permuted block randomization method. The study cohort comprised 34 patients: 19 in the real acupuncture group and 15 in the sham acupuncture group. The clinical characteristics of the patients during their menstrual period were collected, and imaging scans were performed during the first 3 days of the patients’ menstrual period. We analyzed task and resting functional magnetic resonance imaging (fMRI) data to investigate the potential central mechanism of the immediate effect of acupuncture intervention on the intensity of PDM pain. The task fMRI study found that the rostral anterior cingulate cortex (rACC) and right supplemental motor area were activated during real acupuncture. Using the resting-state functional connectivity (FC) method, we found a post- versus pre-treatment change in the FC of the rACC and left precentral gyrus in the comparison of real acupuncture versus sham acupuncture. In addition, the FC of the rACC–left precentral gyrus at baseline was negatively correlated with short-term analgesia, while the change in the FC of the rACC–left precentral gyrus was positively correlated with short-term analgesia after acupuncture treatment. These findings support the importance of rACC–left precentral gyrus resting-state FC in the modulation of the intensity of PDM pain through acupuncture, which may shed light on the central mechanism of acupuncture in the treatment of PDM.
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spelling pubmed-81808462021-06-08 Immediate Analgesic Effect of Acupuncture in Patients With Primary Dysmenorrhea: A fMRI Study Wang, Yanan Xu, Jing Zhang, Qing Zhang, Qi Yang, Ya Wei, Wei Guo, Xiaoli Liang, Fanrong Yu, Siyi Yang, Jie Front Neurosci Neuroscience Primary dysmenorrhea (PDM) is a common gynecological disease characterized by lower abdominal pain. Acupuncture is considered a good alternative therapy for PDM. However, the central mechanism of the analgesic effect of acupuncture is largely unknown. In this study, eligible patients were randomized into the real and sham acupuncture groups using a computer-generated, permuted block randomization method. The study cohort comprised 34 patients: 19 in the real acupuncture group and 15 in the sham acupuncture group. The clinical characteristics of the patients during their menstrual period were collected, and imaging scans were performed during the first 3 days of the patients’ menstrual period. We analyzed task and resting functional magnetic resonance imaging (fMRI) data to investigate the potential central mechanism of the immediate effect of acupuncture intervention on the intensity of PDM pain. The task fMRI study found that the rostral anterior cingulate cortex (rACC) and right supplemental motor area were activated during real acupuncture. Using the resting-state functional connectivity (FC) method, we found a post- versus pre-treatment change in the FC of the rACC and left precentral gyrus in the comparison of real acupuncture versus sham acupuncture. In addition, the FC of the rACC–left precentral gyrus at baseline was negatively correlated with short-term analgesia, while the change in the FC of the rACC–left precentral gyrus was positively correlated with short-term analgesia after acupuncture treatment. These findings support the importance of rACC–left precentral gyrus resting-state FC in the modulation of the intensity of PDM pain through acupuncture, which may shed light on the central mechanism of acupuncture in the treatment of PDM. Frontiers Media S.A. 2021-05-24 /pmc/articles/PMC8180846/ /pubmed/34108856 http://dx.doi.org/10.3389/fnins.2021.647667 Text en Copyright © 2021 Wang, Xu, Zhang, Zhang, Yang, Wei, Guo, Liang, Yu and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Yanan
Xu, Jing
Zhang, Qing
Zhang, Qi
Yang, Ya
Wei, Wei
Guo, Xiaoli
Liang, Fanrong
Yu, Siyi
Yang, Jie
Immediate Analgesic Effect of Acupuncture in Patients With Primary Dysmenorrhea: A fMRI Study
title Immediate Analgesic Effect of Acupuncture in Patients With Primary Dysmenorrhea: A fMRI Study
title_full Immediate Analgesic Effect of Acupuncture in Patients With Primary Dysmenorrhea: A fMRI Study
title_fullStr Immediate Analgesic Effect of Acupuncture in Patients With Primary Dysmenorrhea: A fMRI Study
title_full_unstemmed Immediate Analgesic Effect of Acupuncture in Patients With Primary Dysmenorrhea: A fMRI Study
title_short Immediate Analgesic Effect of Acupuncture in Patients With Primary Dysmenorrhea: A fMRI Study
title_sort immediate analgesic effect of acupuncture in patients with primary dysmenorrhea: a fmri study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180846/
https://www.ncbi.nlm.nih.gov/pubmed/34108856
http://dx.doi.org/10.3389/fnins.2021.647667
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