Exosomes Promote Pre-Metastatic Niche Formation in Gastric Cancer

Gastric cancer has a high rate of metastasis, during which pre-metastatic niches (PMN) provide a supportive environment for the upcoming tumor cells. Exosomes are bilayer vesicles secreted by cells containing biological information that mediates communication between cells. Using exosomes, gastric c...

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Autores principales: Gao, Jing, Li, Song, Xu, Qian, Zhang, Xue, Huang, Miao, Dai, Xin, Liu, Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180914/
https://www.ncbi.nlm.nih.gov/pubmed/34109113
http://dx.doi.org/10.3389/fonc.2021.652378
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author Gao, Jing
Li, Song
Xu, Qian
Zhang, Xue
Huang, Miao
Dai, Xin
Liu, Lian
author_facet Gao, Jing
Li, Song
Xu, Qian
Zhang, Xue
Huang, Miao
Dai, Xin
Liu, Lian
author_sort Gao, Jing
collection PubMed
description Gastric cancer has a high rate of metastasis, during which pre-metastatic niches (PMN) provide a supportive environment for the upcoming tumor cells. Exosomes are bilayer vesicles secreted by cells containing biological information that mediates communication between cells. Using exosomes, gastric cancer cells establish PMN remotely in multifarious perspectives, including immunosuppression, stroma remodeling, angiogenesis, mesothelial mesenchymal transformation, and organotropism. In turn, the cell components in PMN secrete exosomes that interact with each other and provide onco-promoting signals. In this review, we highlight the role of exosomes in PMN formation in gastric cancer and discuss their potential values in gastric cancer metastasis diagnosis, prevention, and treatment.
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spelling pubmed-81809142021-06-08 Exosomes Promote Pre-Metastatic Niche Formation in Gastric Cancer Gao, Jing Li, Song Xu, Qian Zhang, Xue Huang, Miao Dai, Xin Liu, Lian Front Oncol Oncology Gastric cancer has a high rate of metastasis, during which pre-metastatic niches (PMN) provide a supportive environment for the upcoming tumor cells. Exosomes are bilayer vesicles secreted by cells containing biological information that mediates communication between cells. Using exosomes, gastric cancer cells establish PMN remotely in multifarious perspectives, including immunosuppression, stroma remodeling, angiogenesis, mesothelial mesenchymal transformation, and organotropism. In turn, the cell components in PMN secrete exosomes that interact with each other and provide onco-promoting signals. In this review, we highlight the role of exosomes in PMN formation in gastric cancer and discuss their potential values in gastric cancer metastasis diagnosis, prevention, and treatment. Frontiers Media S.A. 2021-05-24 /pmc/articles/PMC8180914/ /pubmed/34109113 http://dx.doi.org/10.3389/fonc.2021.652378 Text en Copyright © 2021 Gao, Li, Xu, Zhang, Huang, Dai and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Gao, Jing
Li, Song
Xu, Qian
Zhang, Xue
Huang, Miao
Dai, Xin
Liu, Lian
Exosomes Promote Pre-Metastatic Niche Formation in Gastric Cancer
title Exosomes Promote Pre-Metastatic Niche Formation in Gastric Cancer
title_full Exosomes Promote Pre-Metastatic Niche Formation in Gastric Cancer
title_fullStr Exosomes Promote Pre-Metastatic Niche Formation in Gastric Cancer
title_full_unstemmed Exosomes Promote Pre-Metastatic Niche Formation in Gastric Cancer
title_short Exosomes Promote Pre-Metastatic Niche Formation in Gastric Cancer
title_sort exosomes promote pre-metastatic niche formation in gastric cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180914/
https://www.ncbi.nlm.nih.gov/pubmed/34109113
http://dx.doi.org/10.3389/fonc.2021.652378
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