T0901317, an Agonist of Liver X Receptors, Attenuates Neuronal Apoptosis in Early Brain Injury after Subarachnoid Hemorrhage in Rats via Liver X Receptors/Interferon Regulatory Factor/P53 Upregulated Modulator of Apoptosis/Dynamin-1-Like Protein Pathway

METHODS: Subarachnoid hemorrhage (SAH) models of Sprague-Dawley rats were established with perforation method. T0901317 was injected intraperitoneally 1-hour post-SAH. GSK2033, an inhibitor of LXRs, and interferon regulatory factor (IRF-1) CRISPR activation were injected intracerebroventricularly to...

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Detalles Bibliográficos
Autores principales: Dai, Jiaxing, Xu, Shancai, Okada, Takeshi, Liu, Yu, Zuo, Gang, Tang, Jiping, Zhang, John H., Shi, Huaizhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181056/
https://www.ncbi.nlm.nih.gov/pubmed/34194609
http://dx.doi.org/10.1155/2021/8849131

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