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Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases

Microglia-mediated neuroinflammation is one of the most remarkable hallmarks of neurodegenerative diseases (NDDs), including AD, PD, and ALS. Accumulating evidence indicates that microglia play both neuroprotective and detrimental roles in the onset and progression of NDDs. Yet, the specific mechani...

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Autores principales: Wang, Li, Yu, Chao-Chao, Liu, Xin-Yuan, Deng, Xiao-Ni, Tian, Qing, Du, Yan-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181095/
https://www.ncbi.nlm.nih.gov/pubmed/34194489
http://dx.doi.org/10.1155/2021/9912686
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author Wang, Li
Yu, Chao-Chao
Liu, Xin-Yuan
Deng, Xiao-Ni
Tian, Qing
Du, Yan-Jun
author_facet Wang, Li
Yu, Chao-Chao
Liu, Xin-Yuan
Deng, Xiao-Ni
Tian, Qing
Du, Yan-Jun
author_sort Wang, Li
collection PubMed
description Microglia-mediated neuroinflammation is one of the most remarkable hallmarks of neurodegenerative diseases (NDDs), including AD, PD, and ALS. Accumulating evidence indicates that microglia play both neuroprotective and detrimental roles in the onset and progression of NDDs. Yet, the specific mechanisms of action surrounding microglia are not clear. Modulation of microglia function and phenotypes appears to be a potential strategy to reverse NDDs. Until recently, research into the epigenetic mechanisms of diseases has been gradually developed, making it possible to elucidate the molecular mechanisms underlying the epigenetic regulation of microglia in NDDs. This review highlights the function and phenotypes of microglia, elucidates the relationship between microglia, epigenetic modifications, and NDDs, as well as the possible mechanisms underlying the epigenetic modulation of microglia in NDDs with a focus on potential intervention strategies.
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spelling pubmed-81810952021-06-29 Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases Wang, Li Yu, Chao-Chao Liu, Xin-Yuan Deng, Xiao-Ni Tian, Qing Du, Yan-Jun Neural Plast Review Article Microglia-mediated neuroinflammation is one of the most remarkable hallmarks of neurodegenerative diseases (NDDs), including AD, PD, and ALS. Accumulating evidence indicates that microglia play both neuroprotective and detrimental roles in the onset and progression of NDDs. Yet, the specific mechanisms of action surrounding microglia are not clear. Modulation of microglia function and phenotypes appears to be a potential strategy to reverse NDDs. Until recently, research into the epigenetic mechanisms of diseases has been gradually developed, making it possible to elucidate the molecular mechanisms underlying the epigenetic regulation of microglia in NDDs. This review highlights the function and phenotypes of microglia, elucidates the relationship between microglia, epigenetic modifications, and NDDs, as well as the possible mechanisms underlying the epigenetic modulation of microglia in NDDs with a focus on potential intervention strategies. Hindawi 2021-05-29 /pmc/articles/PMC8181095/ /pubmed/34194489 http://dx.doi.org/10.1155/2021/9912686 Text en Copyright © 2021 Li Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Li
Yu, Chao-Chao
Liu, Xin-Yuan
Deng, Xiao-Ni
Tian, Qing
Du, Yan-Jun
Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases
title Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases
title_full Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases
title_fullStr Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases
title_full_unstemmed Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases
title_short Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases
title_sort epigenetic modulation of microglia function and phenotypes in neurodegenerative diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181095/
https://www.ncbi.nlm.nih.gov/pubmed/34194489
http://dx.doi.org/10.1155/2021/9912686
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