Cargando…

Metformin Reduces Vascular Assembly in High Glucose-Treated Human Microvascular Endothelial Cells in An AMPK-Independent Manner

OBJECTIVE: The aim is to examine the effect of metformin in human microvascular endothelial cells exposed to high glucose (HG) concentration and compare them with the effects of other 5' adenosine monophosphate-activated protein kinase (AMPK) modulators under the same condition. MATERIALS AND M...

Descripción completa

Detalles Bibliográficos
Autores principales:	Silva, Carolina, Rodrigues, Ilda, Andrade, Sara, Costa, Raquel, Soares, Raquel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royan Institute 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181317/ https://www.ncbi.nlm.nih.gov/pubmed/34096218 http://dx.doi.org/10.22074/cellj.2021.7212

Ejemplares similares

Establishing a Link between Endothelial Cell Metabolism and Vascular Behaviour in a Type 1 Diabetes Mouse Model
por: Silva, Carolina, et al.
Publicado: (2019)

AMPK Phosphorylation Is Controlled by Glucose Transport Rate in a PKA-Independent Manner
por: Milanesi, Riccardo, et al.
Publicado: (2021)

Dual Effects of Metformin on Adipogenic Differentiation of 3T3-L1 Preadipocyte in AMPK-Dependent and Independent Manners
por: Chen, Dian, et al.
Publicado: (2018)

Metformin attenuates high glucose-induced injury in islet microvascular endothelial cells
por: Zou, Wenyu, et al.
Publicado: (2022)

AMPK promotes Arf6 activation in a kinase-independent manner upon glucose starvation
por: Chen, Kuan-Jung, et al.
Publicado: (2022)

Metformin Treatment Reduces CRC Aggressiveness in a Glucose-Independent Manner: An In Vitro and Ex Vivo Study
por: Boutaud, Marie, et al.
Publicado: (2023)

Fasentin diminishes endothelial cell proliferation, differentiation and invasion in a glucose metabolism-independent manner
por: Ocaña, Mª Carmen, et al.
Publicado: (2020)

Hyperoxia Reprogrammes Microvascular Endothelial Cell Response to Hypoxia in an Organ-Specific Manner
por: Reiterer, Moritz, et al.
Publicado: (2022)

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms
por: Chen, Suet Ching, et al.
Publicado: (2017)

Metformin inhibits gastric cancer cells metastatic traits through suppression of epithelial-mesenchymal transition in a glucose-independent manner
por: Valaee, Shiva, et al.
Publicado: (2017)

Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons
por: Bayliss, Jacqueline A., et al.
Publicado: (2016)

Biocompatibility of the Biopolymer Cyanoflan for Applications in Skin Wound Healing
por: Costa, Raquel, et al.
Publicado: (2021)

The importance of the AMPK gamma 1 subunit in metformin suppression of liver glucose production
por: An, Hongying, et al.
Publicado: (2020)

Heparanase mediates vascular endothelial growth factor gene transcription in high-glucose human retinal microvascular endothelial cells
por: Hu, Jie, et al.
Publicado: (2017)

Metformin Modulates High Glucose-Incubated Human Umbilical Vein Endothelial Cells Proliferation and Apoptosis Through AMPK/CREB/BDNF Pathway
por: Han, Xiqiong, et al.
Publicado: (2018)

Resveratrol alleviates high glucose-induced oxidative stress and apoptosis in rat cardiac microvascular endothelial cell through AMPK/Sirt1 activation
por: Li, Jinyu, et al.
Publicado: (2023)

Palbociclib induces activation of AMPK and inhibits hepatocellular carcinoma in a CDK4/6‐independent manner
por: Hsieh, Feng‐Shu, et al.
Publicado: (2017)

Activating AMPK to Restore Tight Junction Assembly in Intestinal Epithelium and to Attenuate Experimental Colitis by Metformin
por: Chen, Lu, et al.
Publicado: (2018)

Otic Neurogenesis Is Regulated by TGFβ in a Senescence-Independent Manner
por: Magariños, Marta, et al.
Publicado: (2020)

SCFβ‐TrCP ubiquitinates CHK1 in an AMPK‐dependent manner in response to glucose deprivation
por: Ma, Ying, et al.
Publicado: (2018)

Metformin Inhibits Tumor Metastasis through Suppressing Hsp90α Secretion in an AMPKα1-PKCγ Dependent Manner
por: Gong, Yuanchao, et al.
Publicado: (2020)

Glucose Inhibits Yeast AMPK (Snf1) by Three Independent Mechanisms
por: Simpson-Lavy, Kobi, et al.
Publicado: (2023)

Metabolic regulation by the intestinal metformin-AMPK axis
por: Zhang, Song-Yang, et al.
Publicado: (2022)

Chronic Exercise Training Improved Aortic Endothelial and Mitochondrial Function via an AMPKα2-Dependent Manner
por: Chen, Xiaohui, et al.
Publicado: (2016)

Dynamic glucose uptake, storage, and release by human microvascular endothelial cells
por: Yazdani, Samaneh, et al.
Publicado: (2022)

Xanthohumol and 8-prenylnaringenin reduce type 2 diabetes–associated oxidative stress by downregulating galectin-3
por: Luís, Carla, et al.
Publicado: (2018)

Inhibition of mitochondrial complex I improves glucose metabolism independently of AMPK activation
por: Hou, Wo‐Lin, et al.
Publicado: (2017)

Anti-angiogenic Effects of Metformin, an AMPK Activator, on Human Umbilical Vein Endothelial Cells and on Granulation Tissue in Rat
por: Soraya, Hamid, et al.
Publicado: (2012)

AMPK-Dependent YAP Inhibition Mediates the Protective Effect of Metformin against Obesity-Associated Endothelial Dysfunction and Inflammation
por: Kang, Lijing, et al.
Publicado: (2023)

Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells
por: Ming, Ming, et al.
Publicado: (2014)

Non-Lethal Doses of RSL3 Impair Microvascular Endothelial Barrier through Degradation of Sphingosie-1-Phosphate Receptor 1 and Cytoskeletal Arrangement in A Ferroptosis-Independent Manner
por: Baoyinna, Boina, et al.
Publicado: (2023)

Metformin and glucose starvation decrease the migratory ability of hepatocellular carcinoma cells: targeting AMPK activation to control migration
por: Ferretti, Anabela C., et al.
Publicado: (2019)

Coronary microvascular endothelial dysfunction is an independent predictor of development of osteoporosis in postmenopausal women
por: Prasad, Megha, et al.
Publicado: (2014)

The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective
por: Agius, Loranne, et al.
Publicado: (2020)

Demystifying the Relationship Between Metformin, AMPK, and Doxorubicin Cardiotoxicity
por: Singh, Manrose, et al.
Publicado: (2022)

RNF213 Loss-of-Function Promotes Angiogenesis of Cerebral Microvascular Endothelial Cells in a Cellular State Dependent Manner
por: Roy, Vincent, et al.
Publicado: (2022)

Microvascularization and Expression of Fibroblast Growth Factor and Vascular Endothelial Growth Factor and Their Receptors in the Mare Oviduct
por: Pinto-Bravo, Pedro, et al.
Publicado: (2021)

Phenelzine and Amoxapine Inhibit Tyramine and d-Glucuronic Acid Catabolism in Clinically Significant Salmonella in A Serotype-Independent Manner
por: Burin, Raquel, et al.
Publicado: (2021)

Liraglutide Lowers Endothelial Vascular Cell Adhesion Molecule-1 in Murine Atherosclerosis Independent of Glucose Levels
por: Punjabi, Mukesh, et al.
Publicado: (2022)

Electroporation of human microvascular endothelial cells: evidence for an anti-vascular mechanism of electrochemotherapy
por: Cemazar, M, et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_656039lak868naliht086v9jqh