Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling

Natural killer (NK) cells are innate effector lymphocytes with strong antitumor effects against hematologic malignancies such as chronic lymphocytic leukemia (CLL). However, NK cells fail to control CLL progression on the long term. For effective lysis of their targets, NK cells use a specific cell-...

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Detalles Bibliográficos
Autores principales: Wurzer, Hannah, Filali, Liza, Hoffmann, Céline, Krecke, Max, Biolato, Andrea Michela, Mastio, Jérôme, De Wilde, Sigrid, François, Jean Hugues, Largeot, Anne, Berchem, Guy, Paggetti, Jérôme, Moussay, Etienne, Thomas, Clément
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181408/
https://www.ncbi.nlm.nih.gov/pubmed/34108958
http://dx.doi.org/10.3389/fimmu.2021.619069

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