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COL4A3 expression in asthmatic epithelium depends on intronic methylation and ZNF263 binding

BACKGROUND: Reduction of COL4A3, one of the six isoforms of collagen 4, in asthmatic airways results in increased inflammation and angiogenesis, implicating it as a central part of asthma pathogenesis. However, to date, the path underlying these diminished COL4A3 levels has been elusive. This study...

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Detalles Bibliográficos
Autores principales:	Nemani, Sai Sneha Priya, Vermeulen, Cornelis Joseph, Pech, Martin, Faiz, Alen, Oliver, Brian George G., van den Berge, Maarten, Burgess, Janette Kay, Kopp, Matthias V., Weckmann, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Respiratory Society 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181658/ https://www.ncbi.nlm.nih.gov/pubmed/34109240 http://dx.doi.org/10.1183/23120541.00802-2020

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