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Cardiorespiratory Coordination in Hypercapnic Test Before and After High-Altitude Expedition
Coordination of cardiovascular and respiratory systems enables a wide range of human adaptation and depends upon the functional state of an individual organism. Hypoxia is known to elicit changes in oxygen and carbon dioxide sensitivity, while training alters cardiorespiratory coordination (CRC). Th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181754/ https://www.ncbi.nlm.nih.gov/pubmed/34108888 http://dx.doi.org/10.3389/fphys.2021.673570 |
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author | Gultyaeva, Valentina V. Uryumtsev, Dmitriy Y. Zinchenko, Margarita I. Melnikov, Vladimir N. Balioz, Natalia V. Krivoschekov, Sergey G. |
author_facet | Gultyaeva, Valentina V. Uryumtsev, Dmitriy Y. Zinchenko, Margarita I. Melnikov, Vladimir N. Balioz, Natalia V. Krivoschekov, Sergey G. |
author_sort | Gultyaeva, Valentina V. |
collection | PubMed |
description | Coordination of cardiovascular and respiratory systems enables a wide range of human adaptation and depends upon the functional state of an individual organism. Hypoxia is known to elicit changes in oxygen and carbon dioxide sensitivity, while training alters cardiorespiratory coordination (CRC). The delayed effect of high altitude (HA) acclimatization on CRC in mountaineers remains unknown. The objective of this study was to compare CRC in acute hypercapnia in mountaineers before and after a HA expedition. Nine trained male mountaineers were investigated at sea level before (Pre-HA) and after a 20-day sojourn at altitudes of 4,000–7,000 m (Post-HA) in three states (Baseline, Hypercapnic Rebreathing, and Recovery). A principal component (PC) analysis was performed to evaluate the CRC. The number of mountaineers with one PC increased Post-HA (nine out of nine), compared to Pre-HA (five out of nine) [Chi-square (df = 1) = 5.14, P = 0.023]; the percentage of total variance explained by PC1 increased [Pre-HA median 65.6 (Q1 64.9/Q3 74.9), Post-HA 75.6 (73.3/77.9), P = 0.028]. Post-HA, the loadings of the expired fraction of O2, CO2, and ventilation onto PC1 did not change, and the loading of heart rate increased [Pre-HA 0.64 (0.45/0.68) and Post-HA 0.76 (0.65/0.82), P = 0.038]. During the Recovery, the percentage of total variance explained by PC1 was higher than during the Baseline. Post-HA, there was a high correlation between the Exercise addiction scores and the eigenvalues of PC1 (r = 0.9, P = 0.001). Thus, acute hypercapnic exposure reveals the Post-HA increase in cardiorespiratory coordination, which is highly related to the level of exercise addiction. |
format | Online Article Text |
id | pubmed-8181754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81817542021-06-08 Cardiorespiratory Coordination in Hypercapnic Test Before and After High-Altitude Expedition Gultyaeva, Valentina V. Uryumtsev, Dmitriy Y. Zinchenko, Margarita I. Melnikov, Vladimir N. Balioz, Natalia V. Krivoschekov, Sergey G. Front Physiol Physiology Coordination of cardiovascular and respiratory systems enables a wide range of human adaptation and depends upon the functional state of an individual organism. Hypoxia is known to elicit changes in oxygen and carbon dioxide sensitivity, while training alters cardiorespiratory coordination (CRC). The delayed effect of high altitude (HA) acclimatization on CRC in mountaineers remains unknown. The objective of this study was to compare CRC in acute hypercapnia in mountaineers before and after a HA expedition. Nine trained male mountaineers were investigated at sea level before (Pre-HA) and after a 20-day sojourn at altitudes of 4,000–7,000 m (Post-HA) in three states (Baseline, Hypercapnic Rebreathing, and Recovery). A principal component (PC) analysis was performed to evaluate the CRC. The number of mountaineers with one PC increased Post-HA (nine out of nine), compared to Pre-HA (five out of nine) [Chi-square (df = 1) = 5.14, P = 0.023]; the percentage of total variance explained by PC1 increased [Pre-HA median 65.6 (Q1 64.9/Q3 74.9), Post-HA 75.6 (73.3/77.9), P = 0.028]. Post-HA, the loadings of the expired fraction of O2, CO2, and ventilation onto PC1 did not change, and the loading of heart rate increased [Pre-HA 0.64 (0.45/0.68) and Post-HA 0.76 (0.65/0.82), P = 0.038]. During the Recovery, the percentage of total variance explained by PC1 was higher than during the Baseline. Post-HA, there was a high correlation between the Exercise addiction scores and the eigenvalues of PC1 (r = 0.9, P = 0.001). Thus, acute hypercapnic exposure reveals the Post-HA increase in cardiorespiratory coordination, which is highly related to the level of exercise addiction. Frontiers Media S.A. 2021-05-24 /pmc/articles/PMC8181754/ /pubmed/34108888 http://dx.doi.org/10.3389/fphys.2021.673570 Text en Copyright © 2021 Gultyaeva, Uryumtsev, Zinchenko, Melnikov, Balioz and Krivoschekov. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Gultyaeva, Valentina V. Uryumtsev, Dmitriy Y. Zinchenko, Margarita I. Melnikov, Vladimir N. Balioz, Natalia V. Krivoschekov, Sergey G. Cardiorespiratory Coordination in Hypercapnic Test Before and After High-Altitude Expedition |
title | Cardiorespiratory Coordination in Hypercapnic Test Before and After High-Altitude Expedition |
title_full | Cardiorespiratory Coordination in Hypercapnic Test Before and After High-Altitude Expedition |
title_fullStr | Cardiorespiratory Coordination in Hypercapnic Test Before and After High-Altitude Expedition |
title_full_unstemmed | Cardiorespiratory Coordination in Hypercapnic Test Before and After High-Altitude Expedition |
title_short | Cardiorespiratory Coordination in Hypercapnic Test Before and After High-Altitude Expedition |
title_sort | cardiorespiratory coordination in hypercapnic test before and after high-altitude expedition |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181754/ https://www.ncbi.nlm.nih.gov/pubmed/34108888 http://dx.doi.org/10.3389/fphys.2021.673570 |
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