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Prognostic Role of High Sensitivity C-Reactive Protein in Patients With Acute Myocardial Infarction

Background: High sensitivity CRP (hs-CRP) has attracted intense interest in risk assessment. We aimed to explore its prognostic value in patients with acute myocardial infarction (AMI). Methods and Results: We enrolled 4,504 consecutive AMI patients in this prospective cohort study. The associations...

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Autores principales: Zhang, Xiaoyuan, Wang, Shanjie, Fang, Shaohong, Yu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181755/
https://www.ncbi.nlm.nih.gov/pubmed/34109224
http://dx.doi.org/10.3389/fcvm.2021.659446
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author Zhang, Xiaoyuan
Wang, Shanjie
Fang, Shaohong
Yu, Bo
author_facet Zhang, Xiaoyuan
Wang, Shanjie
Fang, Shaohong
Yu, Bo
author_sort Zhang, Xiaoyuan
collection PubMed
description Background: High sensitivity CRP (hs-CRP) has attracted intense interest in risk assessment. We aimed to explore its prognostic value in patients with acute myocardial infarction (AMI). Methods and Results: We enrolled 4,504 consecutive AMI patients in this prospective cohort study. The associations between hs-CRP levels with the incidence of in-hospital HF was evaluated by logistic regression analysis. The association between hs-CRP levels and the cumulative incidence of HF after hospitalization were evaluated by Fine-Gray proportional sub-distribution hazards models, accounting for death without HF as competing risk. Cox proportional hazards regression models were constructed to estimate the association between hs-CRP levels and the risk of all-cause mortality. Over a median follow-up of 1 year, 1,112 (24.7%) patients developed in-hospital HF, 571 (18.9%) patients developed HF post-discharge and 262 (8.2%) patients died. In the fully adjusted model, the risk of in-hospital heart failure (HF) [95% confidence intervals (CI)] among those patients with hs-CRP values in quartile 3 (Q3) and Q4 were 1.36 (1.05–1.77) and 1.41 (1.07–1.85) times as high as the risk among patients in Q1 (p trend < 0.001). Patients with hs-CRP values in Q3 and Q4 had 1.33 (1.00–1.76) and 1.80 times (1.37–2.36) as high as the risk of HF post-discharge compared with patients in Q1 respectively (p trend < 0.001). Patients with hs-CRP values in Q3 and Q4 had 1.74 (1.08–2.82) and 2.42 times (1.52–3.87) as high as the risk of death compared with patients in Q1 respectively (p trend < 0.001). Conclusions: Hs-CRP was found to be associated with the incidence of in-hospital HF, HF post-discharge and all-cause mortality in patients with AMI.
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spelling pubmed-81817552021-06-08 Prognostic Role of High Sensitivity C-Reactive Protein in Patients With Acute Myocardial Infarction Zhang, Xiaoyuan Wang, Shanjie Fang, Shaohong Yu, Bo Front Cardiovasc Med Cardiovascular Medicine Background: High sensitivity CRP (hs-CRP) has attracted intense interest in risk assessment. We aimed to explore its prognostic value in patients with acute myocardial infarction (AMI). Methods and Results: We enrolled 4,504 consecutive AMI patients in this prospective cohort study. The associations between hs-CRP levels with the incidence of in-hospital HF was evaluated by logistic regression analysis. The association between hs-CRP levels and the cumulative incidence of HF after hospitalization were evaluated by Fine-Gray proportional sub-distribution hazards models, accounting for death without HF as competing risk. Cox proportional hazards regression models were constructed to estimate the association between hs-CRP levels and the risk of all-cause mortality. Over a median follow-up of 1 year, 1,112 (24.7%) patients developed in-hospital HF, 571 (18.9%) patients developed HF post-discharge and 262 (8.2%) patients died. In the fully adjusted model, the risk of in-hospital heart failure (HF) [95% confidence intervals (CI)] among those patients with hs-CRP values in quartile 3 (Q3) and Q4 were 1.36 (1.05–1.77) and 1.41 (1.07–1.85) times as high as the risk among patients in Q1 (p trend < 0.001). Patients with hs-CRP values in Q3 and Q4 had 1.33 (1.00–1.76) and 1.80 times (1.37–2.36) as high as the risk of HF post-discharge compared with patients in Q1 respectively (p trend < 0.001). Patients with hs-CRP values in Q3 and Q4 had 1.74 (1.08–2.82) and 2.42 times (1.52–3.87) as high as the risk of death compared with patients in Q1 respectively (p trend < 0.001). Conclusions: Hs-CRP was found to be associated with the incidence of in-hospital HF, HF post-discharge and all-cause mortality in patients with AMI. Frontiers Media S.A. 2021-05-24 /pmc/articles/PMC8181755/ /pubmed/34109224 http://dx.doi.org/10.3389/fcvm.2021.659446 Text en Copyright © 2021 Zhang, Wang, Fang and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Zhang, Xiaoyuan
Wang, Shanjie
Fang, Shaohong
Yu, Bo
Prognostic Role of High Sensitivity C-Reactive Protein in Patients With Acute Myocardial Infarction
title Prognostic Role of High Sensitivity C-Reactive Protein in Patients With Acute Myocardial Infarction
title_full Prognostic Role of High Sensitivity C-Reactive Protein in Patients With Acute Myocardial Infarction
title_fullStr Prognostic Role of High Sensitivity C-Reactive Protein in Patients With Acute Myocardial Infarction
title_full_unstemmed Prognostic Role of High Sensitivity C-Reactive Protein in Patients With Acute Myocardial Infarction
title_short Prognostic Role of High Sensitivity C-Reactive Protein in Patients With Acute Myocardial Infarction
title_sort prognostic role of high sensitivity c-reactive protein in patients with acute myocardial infarction
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181755/
https://www.ncbi.nlm.nih.gov/pubmed/34109224
http://dx.doi.org/10.3389/fcvm.2021.659446
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