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High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway

Podocytes are the major target in proteinuric kidney diseases such as diabetic nephropathy. The underlying molecular mechanisms by which high glucose (HG) results in podocyte damage remain unclear. This study investigated the regulatory role of Smad3, ezrin, and protein kinase A (PKA) in NADPH oxida...

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Detalles Bibliográficos
Autores principales:	Guo, Wanxu, Gao, Hang, Pan, Wei, Yu, Panapn, Che, Guanghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181897/ https://www.ncbi.nlm.nih.gov/pubmed/33046439 http://dx.doi.org/10.1242/bio.055012

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