Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study

Corticosteroids reduced mortality rate in patients with coronavirus disease 2019 (COVID-19). Previously, we hypothesized that corticosteroids mitigate the inflammation response resulting in reduced coagulation and thrombosis. In this retrospective study, we included 27 patients with COVID-19 that re...

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Autores principales: Tromp, Katja, van der Zee, Philip, Rokx, Casper, van Kampen, Jeroen, Gommers, Diederik, Endeman, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182185/
https://www.ncbi.nlm.nih.gov/pubmed/34158797
http://dx.doi.org/10.1177/11772719211021647
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author Tromp, Katja
van der Zee, Philip
Rokx, Casper
van Kampen, Jeroen
Gommers, Diederik
Endeman, Henrik
author_facet Tromp, Katja
van der Zee, Philip
Rokx, Casper
van Kampen, Jeroen
Gommers, Diederik
Endeman, Henrik
author_sort Tromp, Katja
collection PubMed
description Corticosteroids reduced mortality rate in patients with coronavirus disease 2019 (COVID-19). Previously, we hypothesized that corticosteroids mitigate the inflammation response resulting in reduced coagulation and thrombosis. In this retrospective study, we included 27 patients with COVID-19 that received high-dose corticosteroids (methylprednisolone 1000 mg i.v. daily for 3 days) for persistent respiratory failure or an excessive inflammation response. We found that inflammation, coagulation, and ventilation parameters improved significantly after methylprednisolone. The viral loads of SARS-CoV-2 remained stable or decreased. These results provides insight into the reduced mortality rate observed in patients with COVID-19 treated with corticosteroids.
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spelling pubmed-81821852021-06-21 Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study Tromp, Katja van der Zee, Philip Rokx, Casper van Kampen, Jeroen Gommers, Diederik Endeman, Henrik Biomark Insights Letter to the Editor Corticosteroids reduced mortality rate in patients with coronavirus disease 2019 (COVID-19). Previously, we hypothesized that corticosteroids mitigate the inflammation response resulting in reduced coagulation and thrombosis. In this retrospective study, we included 27 patients with COVID-19 that received high-dose corticosteroids (methylprednisolone 1000 mg i.v. daily for 3 days) for persistent respiratory failure or an excessive inflammation response. We found that inflammation, coagulation, and ventilation parameters improved significantly after methylprednisolone. The viral loads of SARS-CoV-2 remained stable or decreased. These results provides insight into the reduced mortality rate observed in patients with COVID-19 treated with corticosteroids. SAGE Publications 2021-06-04 /pmc/articles/PMC8182185/ /pubmed/34158797 http://dx.doi.org/10.1177/11772719211021647 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Letter to the Editor
Tromp, Katja
van der Zee, Philip
Rokx, Casper
van Kampen, Jeroen
Gommers, Diederik
Endeman, Henrik
Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study
title Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study
title_full Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study
title_fullStr Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study
title_full_unstemmed Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study
title_short Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study
title_sort effect of methylprednisolone on inflammation and coagulation in patients with severe covid-19: a retrospective cohort study
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182185/
https://www.ncbi.nlm.nih.gov/pubmed/34158797
http://dx.doi.org/10.1177/11772719211021647
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