Histopathological changes in the pancreas due to decreased pancreatic blood flow in a canine tachycardia-induced cardiomyopathy model

In dogs, pancreatic acinar cell injury is thought to be caused by decreased pancreatic blood flow due to heart failure. In previous our report, it demonstrated that decreased heart function causes a significant decrease in pancreatic blood flow in heart failure dog model caused by rapid ventricular...

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Autores principales: YOSHIMURA, Aritada, OHMORI, Takahiro, ITOU, Kokoro, ISHI, Ryo, MATSUMURA, Yuri, WADA, Yuhei, KISHIMOTO, Miori, IWANAGA, Tomoko, MIURA, Naoki, SUZUKI, Kazuhiko, FUKUSHIMA, Ryuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182311/
https://www.ncbi.nlm.nih.gov/pubmed/33716230
http://dx.doi.org/10.1292/jvms.20-0409
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author YOSHIMURA, Aritada
OHMORI, Takahiro
ITOU, Kokoro
ISHI, Ryo
MATSUMURA, Yuri
WADA, Yuhei
KISHIMOTO, Miori
IWANAGA, Tomoko
MIURA, Naoki
SUZUKI, Kazuhiko
FUKUSHIMA, Ryuji
author_facet YOSHIMURA, Aritada
OHMORI, Takahiro
ITOU, Kokoro
ISHI, Ryo
MATSUMURA, Yuri
WADA, Yuhei
KISHIMOTO, Miori
IWANAGA, Tomoko
MIURA, Naoki
SUZUKI, Kazuhiko
FUKUSHIMA, Ryuji
author_sort YOSHIMURA, Aritada
collection PubMed
description In dogs, pancreatic acinar cell injury is thought to be caused by decreased pancreatic blood flow due to heart failure. In previous our report, it demonstrated that decreased heart function causes a significant decrease in pancreatic blood flow in heart failure dog model caused by rapid ventricular pacing (RVP). However, the types of histopathological changes remain unclear. We aimed to verify the types of histopathological changes occurring in the pancreatic tissue due to decreased heart function. After RVP for 4 weeks, atrophy of pancreatic acinar cells, characterized by a decrease in zymogen granules, was observed in all areas of the pancreas. In conclusion, the result of this study suggests that attention should be paid to ischemia/hypoperfusion injury in the pancreas.
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spelling pubmed-81823112021-06-09 Histopathological changes in the pancreas due to decreased pancreatic blood flow in a canine tachycardia-induced cardiomyopathy model YOSHIMURA, Aritada OHMORI, Takahiro ITOU, Kokoro ISHI, Ryo MATSUMURA, Yuri WADA, Yuhei KISHIMOTO, Miori IWANAGA, Tomoko MIURA, Naoki SUZUKI, Kazuhiko FUKUSHIMA, Ryuji J Vet Med Sci Internal Medicine In dogs, pancreatic acinar cell injury is thought to be caused by decreased pancreatic blood flow due to heart failure. In previous our report, it demonstrated that decreased heart function causes a significant decrease in pancreatic blood flow in heart failure dog model caused by rapid ventricular pacing (RVP). However, the types of histopathological changes remain unclear. We aimed to verify the types of histopathological changes occurring in the pancreatic tissue due to decreased heart function. After RVP for 4 weeks, atrophy of pancreatic acinar cells, characterized by a decrease in zymogen granules, was observed in all areas of the pancreas. In conclusion, the result of this study suggests that attention should be paid to ischemia/hypoperfusion injury in the pancreas. The Japanese Society of Veterinary Science 2021-03-15 2021-05 /pmc/articles/PMC8182311/ /pubmed/33716230 http://dx.doi.org/10.1292/jvms.20-0409 Text en ©2021 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Internal Medicine
YOSHIMURA, Aritada
OHMORI, Takahiro
ITOU, Kokoro
ISHI, Ryo
MATSUMURA, Yuri
WADA, Yuhei
KISHIMOTO, Miori
IWANAGA, Tomoko
MIURA, Naoki
SUZUKI, Kazuhiko
FUKUSHIMA, Ryuji
Histopathological changes in the pancreas due to decreased pancreatic blood flow in a canine tachycardia-induced cardiomyopathy model
title Histopathological changes in the pancreas due to decreased pancreatic blood flow in a canine tachycardia-induced cardiomyopathy model
title_full Histopathological changes in the pancreas due to decreased pancreatic blood flow in a canine tachycardia-induced cardiomyopathy model
title_fullStr Histopathological changes in the pancreas due to decreased pancreatic blood flow in a canine tachycardia-induced cardiomyopathy model
title_full_unstemmed Histopathological changes in the pancreas due to decreased pancreatic blood flow in a canine tachycardia-induced cardiomyopathy model
title_short Histopathological changes in the pancreas due to decreased pancreatic blood flow in a canine tachycardia-induced cardiomyopathy model
title_sort histopathological changes in the pancreas due to decreased pancreatic blood flow in a canine tachycardia-induced cardiomyopathy model
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182311/
https://www.ncbi.nlm.nih.gov/pubmed/33716230
http://dx.doi.org/10.1292/jvms.20-0409
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