Expression of neuronal nitric oxide synthase and renin in dysplastic kidneys of young dogs

Renin and neuronal nitric oxide synthase in the kidney control the renin-angiotensin and tubuloglomerular feedback systems. The present study investigated the expression of renin and neuronal nitric oxide synthase in the dysplastic kidneys of three young dogs. Renin-immunoreactivity, which occurs in...

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Autores principales: YABUKI, Akira, FURUSAWA, Yu, MIYOSHI, Noriaki, TANIGUCHI, Kazuyuki, YAMATO, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2021
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182329/
https://www.ncbi.nlm.nih.gov/pubmed/33814522
http://dx.doi.org/10.1292/jvms.21-0074
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author YABUKI, Akira
FURUSAWA, Yu
MIYOSHI, Noriaki
TANIGUCHI, Kazuyuki
YAMATO, Osamu
author_facet YABUKI, Akira
FURUSAWA, Yu
MIYOSHI, Noriaki
TANIGUCHI, Kazuyuki
YAMATO, Osamu
author_sort YABUKI, Akira
collection PubMed
description Renin and neuronal nitric oxide synthase in the kidney control the renin-angiotensin and tubuloglomerular feedback systems. The present study investigated the expression of renin and neuronal nitric oxide synthase in the dysplastic kidneys of three young dogs. Renin-immunoreactivity, which occurs in the juxtaglomerular and tubular cells of dysplastic kidneys, did not differ from that in the normal kidneys of young dogs. Macula densa cells in the normal kidneys showed neuronal nitric oxide synthase -immunoreactivity, but those in the dysplastic kidneys showed no apparent signals. This observation may be correlated with the pathological mechanisms of renal failure in young dogs.
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spelling pubmed-81823292021-06-09 Expression of neuronal nitric oxide synthase and renin in dysplastic kidneys of young dogs YABUKI, Akira FURUSAWA, Yu MIYOSHI, Noriaki TANIGUCHI, Kazuyuki YAMATO, Osamu J Vet Med Sci Pathology Renin and neuronal nitric oxide synthase in the kidney control the renin-angiotensin and tubuloglomerular feedback systems. The present study investigated the expression of renin and neuronal nitric oxide synthase in the dysplastic kidneys of three young dogs. Renin-immunoreactivity, which occurs in the juxtaglomerular and tubular cells of dysplastic kidneys, did not differ from that in the normal kidneys of young dogs. Macula densa cells in the normal kidneys showed neuronal nitric oxide synthase -immunoreactivity, but those in the dysplastic kidneys showed no apparent signals. This observation may be correlated with the pathological mechanisms of renal failure in young dogs. The Japanese Society of Veterinary Science 2021-04-05 2021-05 /pmc/articles/PMC8182329/ /pubmed/33814522 http://dx.doi.org/10.1292/jvms.21-0074 Text en ©2021 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Pathology
YABUKI, Akira
FURUSAWA, Yu
MIYOSHI, Noriaki
TANIGUCHI, Kazuyuki
YAMATO, Osamu
Expression of neuronal nitric oxide synthase and renin in dysplastic kidneys of young dogs
title Expression of neuronal nitric oxide synthase and renin in dysplastic kidneys of young dogs
title_full Expression of neuronal nitric oxide synthase and renin in dysplastic kidneys of young dogs
title_fullStr Expression of neuronal nitric oxide synthase and renin in dysplastic kidneys of young dogs
title_full_unstemmed Expression of neuronal nitric oxide synthase and renin in dysplastic kidneys of young dogs
title_short Expression of neuronal nitric oxide synthase and renin in dysplastic kidneys of young dogs
title_sort expression of neuronal nitric oxide synthase and renin in dysplastic kidneys of young dogs
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182329/
https://www.ncbi.nlm.nih.gov/pubmed/33814522
http://dx.doi.org/10.1292/jvms.21-0074
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