An SNX10-dependent mechanism downregulates fusion between mature osteoclasts

Homozygosity for the R51Q mutation in sorting nexin 10 (SNX10) inactivates osteoclasts (OCLs) and induces autosomal recessive osteopetrosis in humans and in mice. We show here that the fusion of wild-type murine monocytes to form OCLs is highly regulated, and that its extent is limited by blocking f...

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Detalles Bibliográficos
Autores principales: Barnea-Zohar, Maayan, Winograd-Katz, Sabina E., Shalev, Moran, Arman, Esther, Reuven, Nina, Roth, Lee, Golani, Ofra, Stein, Merle, Thalji, Fadi, Kanaan, Moien, Tuckermann, Jan, Geiger, Benjamin, Elson, Ari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182410/
https://www.ncbi.nlm.nih.gov/pubmed/33975343
http://dx.doi.org/10.1242/jcs.254979

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