Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp.

A recent find of a Marasmius species in Northern Thailand led to the isolation of five unprecedented derivatives of the carotane antibiotic fulvoferruginin (1), fulvoferruginins B–F (2–6). The structures of these sesquiterpenoids were elucidated using HRESIMS, 1D and 2D NMR, as well as CD spectrosco...

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Detalles Bibliográficos
Autores principales: Sandargo, Birthe, Kaysan, Leon, Teponno, Rémy B, Richter, Christian, Thongbai, Benjarong, Surup, Frank, Stadler, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182674/
https://www.ncbi.nlm.nih.gov/pubmed/34136017
http://dx.doi.org/10.3762/bjoc.17.97
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author Sandargo, Birthe
Kaysan, Leon
Teponno, Rémy B
Richter, Christian
Thongbai, Benjarong
Surup, Frank
Stadler, Marc
author_facet Sandargo, Birthe
Kaysan, Leon
Teponno, Rémy B
Richter, Christian
Thongbai, Benjarong
Surup, Frank
Stadler, Marc
author_sort Sandargo, Birthe
collection PubMed
description A recent find of a Marasmius species in Northern Thailand led to the isolation of five unprecedented derivatives of the carotane antibiotic fulvoferruginin (1), fulvoferruginins B–F (2–6). The structures of these sesquiterpenoids were elucidated using HRESIMS, 1D and 2D NMR, as well as CD spectroscopy. Assessing the bioactivity, fulvoferruginin emerged as a potent cytotoxic agent of potential pharmaceutical interest.
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spelling pubmed-81826742021-06-15 Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp. Sandargo, Birthe Kaysan, Leon Teponno, Rémy B Richter, Christian Thongbai, Benjarong Surup, Frank Stadler, Marc Beilstein J Org Chem Full Research Paper A recent find of a Marasmius species in Northern Thailand led to the isolation of five unprecedented derivatives of the carotane antibiotic fulvoferruginin (1), fulvoferruginins B–F (2–6). The structures of these sesquiterpenoids were elucidated using HRESIMS, 1D and 2D NMR, as well as CD spectroscopy. Assessing the bioactivity, fulvoferruginin emerged as a potent cytotoxic agent of potential pharmaceutical interest. Beilstein-Institut 2021-06-04 /pmc/articles/PMC8182674/ /pubmed/34136017 http://dx.doi.org/10.3762/bjoc.17.97 Text en Copyright © 2021, Sandargo et al. https://creativecommons.org/licenses/by/4.0/https://www.beilstein-journals.org/bjoc/terms/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). Please note that the reuse, redistribution and reproduction in particular requires that the author(s) and source are credited and that individual graphics may be subject to special legal provisions. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms/terms)
spellingShingle Full Research Paper
Sandargo, Birthe
Kaysan, Leon
Teponno, Rémy B
Richter, Christian
Thongbai, Benjarong
Surup, Frank
Stadler, Marc
Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp.
title Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp.
title_full Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp.
title_fullStr Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp.
title_full_unstemmed Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp.
title_short Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp.
title_sort analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a thai marasmius sp.
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182674/
https://www.ncbi.nlm.nih.gov/pubmed/34136017
http://dx.doi.org/10.3762/bjoc.17.97
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