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Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances
BACKGROUND: As lymphatic vessel is a major route for solid tumor metastasis, they are considered an essential part of tumor drainage conduits. Apart from forming the walls of lymphatic vessels, lymphatic endothelial cells (LECs) have been found to play multiple other roles in the tumor microenvironm...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182726/ https://www.ncbi.nlm.nih.gov/pubmed/34164274 http://dx.doi.org/10.21037/tlcr-21-40 |
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author | He, Miao He, Qihua Cai, Xiuyu Chen, Zisheng Lao, Shen Deng, Hongsheng Liu, Xiwen Zheng, Yongmei Liu, Xiaoyan Liu, Jun Xie, Zhanhong Yao, Maojin Liang, Wenhua He, Jianxing |
author_facet | He, Miao He, Qihua Cai, Xiuyu Chen, Zisheng Lao, Shen Deng, Hongsheng Liu, Xiwen Zheng, Yongmei Liu, Xiaoyan Liu, Jun Xie, Zhanhong Yao, Maojin Liang, Wenhua He, Jianxing |
author_sort | He, Miao |
collection | PubMed |
description | BACKGROUND: As lymphatic vessel is a major route for solid tumor metastasis, they are considered an essential part of tumor drainage conduits. Apart from forming the walls of lymphatic vessels, lymphatic endothelial cells (LECs) have been found to play multiple other roles in the tumor microenvironment, calling for a more in-depth review. We hope that this review may help researchers gain a detailed understanding of this fast-developing field and shed some light upon future research. METHODS: To achieve an informative review of recent advance, we carefully searched the Medline database for English literature that are openly published from the January 1995 to December 2020 and covered the topic of LEC or lymphangiogenesis in tumor progression and therapies. Two different authors independently examined the literature abstracts to exclude possible unqualified ones, and 310 papers with full texts were finally retrieved. RESULTS: In this paper, we discussed the structural and molecular basis of tumor-associated LECs, together with their roles in tumor metastasis and drug therapy. We then focused on their impacts on tumor cells, tumor stroma, and anti-tumor immunity, and the molecular and cellular mechanisms involved. Special emphasis on lung cancer and possible therapeutic targets based on LECs were also discussed. CONCLUSIONS: LECs can play a much more complex role than simply forming conduits for tumor cell dissemination. Therapies targeting tumor-associated lymphatics for lung cancer and other tumors are promising, but more research is needed to clarify the mechanisms involved. |
format | Online Article Text |
id | pubmed-8182726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-81827262021-06-22 Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances He, Miao He, Qihua Cai, Xiuyu Chen, Zisheng Lao, Shen Deng, Hongsheng Liu, Xiwen Zheng, Yongmei Liu, Xiaoyan Liu, Jun Xie, Zhanhong Yao, Maojin Liang, Wenhua He, Jianxing Transl Lung Cancer Res Review Article BACKGROUND: As lymphatic vessel is a major route for solid tumor metastasis, they are considered an essential part of tumor drainage conduits. Apart from forming the walls of lymphatic vessels, lymphatic endothelial cells (LECs) have been found to play multiple other roles in the tumor microenvironment, calling for a more in-depth review. We hope that this review may help researchers gain a detailed understanding of this fast-developing field and shed some light upon future research. METHODS: To achieve an informative review of recent advance, we carefully searched the Medline database for English literature that are openly published from the January 1995 to December 2020 and covered the topic of LEC or lymphangiogenesis in tumor progression and therapies. Two different authors independently examined the literature abstracts to exclude possible unqualified ones, and 310 papers with full texts were finally retrieved. RESULTS: In this paper, we discussed the structural and molecular basis of tumor-associated LECs, together with their roles in tumor metastasis and drug therapy. We then focused on their impacts on tumor cells, tumor stroma, and anti-tumor immunity, and the molecular and cellular mechanisms involved. Special emphasis on lung cancer and possible therapeutic targets based on LECs were also discussed. CONCLUSIONS: LECs can play a much more complex role than simply forming conduits for tumor cell dissemination. Therapies targeting tumor-associated lymphatics for lung cancer and other tumors are promising, but more research is needed to clarify the mechanisms involved. AME Publishing Company 2021-05 /pmc/articles/PMC8182726/ /pubmed/34164274 http://dx.doi.org/10.21037/tlcr-21-40 Text en 2021 Translational Lung Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Review Article He, Miao He, Qihua Cai, Xiuyu Chen, Zisheng Lao, Shen Deng, Hongsheng Liu, Xiwen Zheng, Yongmei Liu, Xiaoyan Liu, Jun Xie, Zhanhong Yao, Maojin Liang, Wenhua He, Jianxing Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances |
title | Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances |
title_full | Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances |
title_fullStr | Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances |
title_full_unstemmed | Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances |
title_short | Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances |
title_sort | role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182726/ https://www.ncbi.nlm.nih.gov/pubmed/34164274 http://dx.doi.org/10.21037/tlcr-21-40 |
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