Cargando…

Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances

BACKGROUND: As lymphatic vessel is a major route for solid tumor metastasis, they are considered an essential part of tumor drainage conduits. Apart from forming the walls of lymphatic vessels, lymphatic endothelial cells (LECs) have been found to play multiple other roles in the tumor microenvironm...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Miao, He, Qihua, Cai, Xiuyu, Chen, Zisheng, Lao, Shen, Deng, Hongsheng, Liu, Xiwen, Zheng, Yongmei, Liu, Xiaoyan, Liu, Jun, Xie, Zhanhong, Yao, Maojin, Liang, Wenhua, He, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182726/
https://www.ncbi.nlm.nih.gov/pubmed/34164274
http://dx.doi.org/10.21037/tlcr-21-40
_version_ 1783704266315137024
author He, Miao
He, Qihua
Cai, Xiuyu
Chen, Zisheng
Lao, Shen
Deng, Hongsheng
Liu, Xiwen
Zheng, Yongmei
Liu, Xiaoyan
Liu, Jun
Xie, Zhanhong
Yao, Maojin
Liang, Wenhua
He, Jianxing
author_facet He, Miao
He, Qihua
Cai, Xiuyu
Chen, Zisheng
Lao, Shen
Deng, Hongsheng
Liu, Xiwen
Zheng, Yongmei
Liu, Xiaoyan
Liu, Jun
Xie, Zhanhong
Yao, Maojin
Liang, Wenhua
He, Jianxing
author_sort He, Miao
collection PubMed
description BACKGROUND: As lymphatic vessel is a major route for solid tumor metastasis, they are considered an essential part of tumor drainage conduits. Apart from forming the walls of lymphatic vessels, lymphatic endothelial cells (LECs) have been found to play multiple other roles in the tumor microenvironment, calling for a more in-depth review. We hope that this review may help researchers gain a detailed understanding of this fast-developing field and shed some light upon future research. METHODS: To achieve an informative review of recent advance, we carefully searched the Medline database for English literature that are openly published from the January 1995 to December 2020 and covered the topic of LEC or lymphangiogenesis in tumor progression and therapies. Two different authors independently examined the literature abstracts to exclude possible unqualified ones, and 310 papers with full texts were finally retrieved. RESULTS: In this paper, we discussed the structural and molecular basis of tumor-associated LECs, together with their roles in tumor metastasis and drug therapy. We then focused on their impacts on tumor cells, tumor stroma, and anti-tumor immunity, and the molecular and cellular mechanisms involved. Special emphasis on lung cancer and possible therapeutic targets based on LECs were also discussed. CONCLUSIONS: LECs can play a much more complex role than simply forming conduits for tumor cell dissemination. Therapies targeting tumor-associated lymphatics for lung cancer and other tumors are promising, but more research is needed to clarify the mechanisms involved.
format Online
Article
Text
id pubmed-8182726
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher AME Publishing Company
record_format MEDLINE/PubMed
spelling pubmed-81827262021-06-22 Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances He, Miao He, Qihua Cai, Xiuyu Chen, Zisheng Lao, Shen Deng, Hongsheng Liu, Xiwen Zheng, Yongmei Liu, Xiaoyan Liu, Jun Xie, Zhanhong Yao, Maojin Liang, Wenhua He, Jianxing Transl Lung Cancer Res Review Article BACKGROUND: As lymphatic vessel is a major route for solid tumor metastasis, they are considered an essential part of tumor drainage conduits. Apart from forming the walls of lymphatic vessels, lymphatic endothelial cells (LECs) have been found to play multiple other roles in the tumor microenvironment, calling for a more in-depth review. We hope that this review may help researchers gain a detailed understanding of this fast-developing field and shed some light upon future research. METHODS: To achieve an informative review of recent advance, we carefully searched the Medline database for English literature that are openly published from the January 1995 to December 2020 and covered the topic of LEC or lymphangiogenesis in tumor progression and therapies. Two different authors independently examined the literature abstracts to exclude possible unqualified ones, and 310 papers with full texts were finally retrieved. RESULTS: In this paper, we discussed the structural and molecular basis of tumor-associated LECs, together with their roles in tumor metastasis and drug therapy. We then focused on their impacts on tumor cells, tumor stroma, and anti-tumor immunity, and the molecular and cellular mechanisms involved. Special emphasis on lung cancer and possible therapeutic targets based on LECs were also discussed. CONCLUSIONS: LECs can play a much more complex role than simply forming conduits for tumor cell dissemination. Therapies targeting tumor-associated lymphatics for lung cancer and other tumors are promising, but more research is needed to clarify the mechanisms involved. AME Publishing Company 2021-05 /pmc/articles/PMC8182726/ /pubmed/34164274 http://dx.doi.org/10.21037/tlcr-21-40 Text en 2021 Translational Lung Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review Article
He, Miao
He, Qihua
Cai, Xiuyu
Chen, Zisheng
Lao, Shen
Deng, Hongsheng
Liu, Xiwen
Zheng, Yongmei
Liu, Xiaoyan
Liu, Jun
Xie, Zhanhong
Yao, Maojin
Liang, Wenhua
He, Jianxing
Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances
title Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances
title_full Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances
title_fullStr Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances
title_full_unstemmed Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances
title_short Role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances
title_sort role of lymphatic endothelial cells in the tumor microenvironment—a narrative review of recent advances
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182726/
https://www.ncbi.nlm.nih.gov/pubmed/34164274
http://dx.doi.org/10.21037/tlcr-21-40
work_keys_str_mv AT hemiao roleoflymphaticendothelialcellsinthetumormicroenvironmentanarrativereviewofrecentadvances
AT heqihua roleoflymphaticendothelialcellsinthetumormicroenvironmentanarrativereviewofrecentadvances
AT caixiuyu roleoflymphaticendothelialcellsinthetumormicroenvironmentanarrativereviewofrecentadvances
AT chenzisheng roleoflymphaticendothelialcellsinthetumormicroenvironmentanarrativereviewofrecentadvances
AT laoshen roleoflymphaticendothelialcellsinthetumormicroenvironmentanarrativereviewofrecentadvances
AT denghongsheng roleoflymphaticendothelialcellsinthetumormicroenvironmentanarrativereviewofrecentadvances
AT liuxiwen roleoflymphaticendothelialcellsinthetumormicroenvironmentanarrativereviewofrecentadvances
AT zhengyongmei roleoflymphaticendothelialcellsinthetumormicroenvironmentanarrativereviewofrecentadvances
AT liuxiaoyan roleoflymphaticendothelialcellsinthetumormicroenvironmentanarrativereviewofrecentadvances
AT liujun roleoflymphaticendothelialcellsinthetumormicroenvironmentanarrativereviewofrecentadvances
AT xiezhanhong roleoflymphaticendothelialcellsinthetumormicroenvironmentanarrativereviewofrecentadvances
AT yaomaojin roleoflymphaticendothelialcellsinthetumormicroenvironmentanarrativereviewofrecentadvances
AT liangwenhua roleoflymphaticendothelialcellsinthetumormicroenvironmentanarrativereviewofrecentadvances
AT hejianxing roleoflymphaticendothelialcellsinthetumormicroenvironmentanarrativereviewofrecentadvances