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Phase 1 randomized study on the safety, tolerability, and pharmacodynamic cognitive and electrophysiological effects of a dopamine D(1) receptor positive allosteric modulator in patients with schizophrenia

ASP4345, a novel dopamine D(1) receptor positive allosteric modulator, is being evaluated for the treatment of cognitive impairment associated with schizophrenia (CIAS). This phase 1 multiple ascending-dose study (NCT02720263) assessed the safety, tolerability, and pharmacodynamics of ASP4345 in pat...

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Detalles Bibliográficos
Autores principales:	Desai, Amit, Benner, Lauren, Wu, Ruishan, Gertsik, Lev, Maruff, Paul, Light, Gregory A., Uz, Tolga, Marek, Gerard J., Zhu, Tong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182805/ https://www.ncbi.nlm.nih.gov/pubmed/33203954 http://dx.doi.org/10.1038/s41386-020-00908-0

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