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Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data

The angopoietin/tyrosine kinase with immunoglobulin and epidermal growth factor homology domains (Ang/Tie) pathway is an emerging key regulator in vascular development and maintenance. Its relevance to clinicians and basic scientists as a potential therapeutic target in retinal and choroidal vascula...

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Autores principales: Joussen, Antonia M., Ricci, Federico, Paris, Liliana P., Korn, Claudia, Quezada-Ruiz, Carlos, Zarbin, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182896/
https://www.ncbi.nlm.nih.gov/pubmed/33564135
http://dx.doi.org/10.1038/s41433-020-01377-x
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author Joussen, Antonia M.
Ricci, Federico
Paris, Liliana P.
Korn, Claudia
Quezada-Ruiz, Carlos
Zarbin, Marco
author_facet Joussen, Antonia M.
Ricci, Federico
Paris, Liliana P.
Korn, Claudia
Quezada-Ruiz, Carlos
Zarbin, Marco
author_sort Joussen, Antonia M.
collection PubMed
description The angopoietin/tyrosine kinase with immunoglobulin and epidermal growth factor homology domains (Ang/Tie) pathway is an emerging key regulator in vascular development and maintenance. Its relevance to clinicians and basic scientists as a potential therapeutic target in retinal and choroidal vascular diseases is highlighted by recent preclinical and clinical evidence. The Ang/Tie pathway plays an important role in the regulation of vascular stability, in angiogenesis under physiological and pathological conditions, as well as in inflammation. Under physiological conditions, angiopoietin-1 (Ang-1) binds to and phosphorylates the Tie2 receptor, leading to downstream signalling that promotes cell survival and vascular stability. Angiopoietin-2 (Ang-2) is upregulated under pathological conditions and acts as a context-dependent agonist/antagonist of the Ang-1/Tie2 axis, causing vascular destabilisation and sensitising blood vessels to the effects of vascular endothelial growth factor-A (VEGF-A). Ang-2 and VEGF-A synergistically drive vascular leakage, neovascularisation and inflammation, key components of retinal vascular diseases. Preclinical evidence suggests that modulating the Ang/Tie pathway restores vascular stabilisation and reduces inflammation. This review discusses how targeting the Ang/Tie pathway or applying Ang-2/VEGF-A combination therapy may be a valuable therapeutic strategy for restoring vascular stability and reducing inflammation in the treatment of retinal and choroidal vascular diseases.
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spelling pubmed-81828962021-06-08 Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data Joussen, Antonia M. Ricci, Federico Paris, Liliana P. Korn, Claudia Quezada-Ruiz, Carlos Zarbin, Marco Eye (Lond) Review Article The angopoietin/tyrosine kinase with immunoglobulin and epidermal growth factor homology domains (Ang/Tie) pathway is an emerging key regulator in vascular development and maintenance. Its relevance to clinicians and basic scientists as a potential therapeutic target in retinal and choroidal vascular diseases is highlighted by recent preclinical and clinical evidence. The Ang/Tie pathway plays an important role in the regulation of vascular stability, in angiogenesis under physiological and pathological conditions, as well as in inflammation. Under physiological conditions, angiopoietin-1 (Ang-1) binds to and phosphorylates the Tie2 receptor, leading to downstream signalling that promotes cell survival and vascular stability. Angiopoietin-2 (Ang-2) is upregulated under pathological conditions and acts as a context-dependent agonist/antagonist of the Ang-1/Tie2 axis, causing vascular destabilisation and sensitising blood vessels to the effects of vascular endothelial growth factor-A (VEGF-A). Ang-2 and VEGF-A synergistically drive vascular leakage, neovascularisation and inflammation, key components of retinal vascular diseases. Preclinical evidence suggests that modulating the Ang/Tie pathway restores vascular stabilisation and reduces inflammation. This review discusses how targeting the Ang/Tie pathway or applying Ang-2/VEGF-A combination therapy may be a valuable therapeutic strategy for restoring vascular stability and reducing inflammation in the treatment of retinal and choroidal vascular diseases. Nature Publishing Group UK 2021-02-09 2021-05 /pmc/articles/PMC8182896/ /pubmed/33564135 http://dx.doi.org/10.1038/s41433-020-01377-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Joussen, Antonia M.
Ricci, Federico
Paris, Liliana P.
Korn, Claudia
Quezada-Ruiz, Carlos
Zarbin, Marco
Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data
title Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data
title_full Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data
title_fullStr Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data
title_full_unstemmed Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data
title_short Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data
title_sort angiopoietin/tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182896/
https://www.ncbi.nlm.nih.gov/pubmed/33564135
http://dx.doi.org/10.1038/s41433-020-01377-x
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