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Temporal phylogeny and molecular characterization of echovirus 30 associated with aseptic meningitis outbreaks in China

BACKGROUND: An outbreak of aseptic meningitis occurred from June to August 2016, in Inner Mongolia Autonomous Region, China. METHODS: To determine its epidemiological characteristics, etiologic agent, and possible origin, specimens were collected for virus isolation and identification, followed by m...

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Autores principales: Tian, Xiaoling, Han, Zhenzhi, He, Yulong, Sun, Qiang, Wang, Wenrui, Xu, Wenbo, Li, Hongying, Zhang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182919/
https://www.ncbi.nlm.nih.gov/pubmed/34092258
http://dx.doi.org/10.1186/s12985-021-01590-4
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author Tian, Xiaoling
Han, Zhenzhi
He, Yulong
Sun, Qiang
Wang, Wenrui
Xu, Wenbo
Li, Hongying
Zhang, Yong
author_facet Tian, Xiaoling
Han, Zhenzhi
He, Yulong
Sun, Qiang
Wang, Wenrui
Xu, Wenbo
Li, Hongying
Zhang, Yong
author_sort Tian, Xiaoling
collection PubMed
description BACKGROUND: An outbreak of aseptic meningitis occurred from June to August 2016, in Inner Mongolia Autonomous Region, China. METHODS: To determine its epidemiological characteristics, etiologic agent, and possible origin, specimens were collected for virus isolation and identification, followed by molecular epidemiological analysis. RESULTS: A total of 363 patients were clinically diagnosed from June 1st to August 31st 2016, and most cases (63.1%, n = 229) were identified between June 22nd and July 17th, with children aged 6 to 12 years constituting the highest percentage (68.9%, n = 250). All viral isolates from this study belonged to genotype C of echovirus 30 (E30), which dominated transmission in China. To date, two E30 transmission lineages have been identified in China, of which Lineage 2 was predominant. We observed fluctuant progress of E30 genetic diversity, with Lineage 2 contributing to increased genetic diversity after 2002, whereas Lineage 1 was significant for the genetic diversity of E30 before 2002. CONCLUSIONS: We identified the epidemiological and etiological causes of an aseptic meningitis outbreak in Inner Mongolia in 2016, and found that Lineage 2 played an important role in recent outbreaks. Moreover, we found that Gansu province could play an important role in E30 spread and might be a possible origin site. Furthermore, Fujian, Shandong, Taiwan, and Zhejiang provinces also demonstrated significant involvement in E30 evolution and persistence over time in China. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12985-021-01590-4.
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spelling pubmed-81829192021-06-09 Temporal phylogeny and molecular characterization of echovirus 30 associated with aseptic meningitis outbreaks in China Tian, Xiaoling Han, Zhenzhi He, Yulong Sun, Qiang Wang, Wenrui Xu, Wenbo Li, Hongying Zhang, Yong Virol J Research BACKGROUND: An outbreak of aseptic meningitis occurred from June to August 2016, in Inner Mongolia Autonomous Region, China. METHODS: To determine its epidemiological characteristics, etiologic agent, and possible origin, specimens were collected for virus isolation and identification, followed by molecular epidemiological analysis. RESULTS: A total of 363 patients were clinically diagnosed from June 1st to August 31st 2016, and most cases (63.1%, n = 229) were identified between June 22nd and July 17th, with children aged 6 to 12 years constituting the highest percentage (68.9%, n = 250). All viral isolates from this study belonged to genotype C of echovirus 30 (E30), which dominated transmission in China. To date, two E30 transmission lineages have been identified in China, of which Lineage 2 was predominant. We observed fluctuant progress of E30 genetic diversity, with Lineage 2 contributing to increased genetic diversity after 2002, whereas Lineage 1 was significant for the genetic diversity of E30 before 2002. CONCLUSIONS: We identified the epidemiological and etiological causes of an aseptic meningitis outbreak in Inner Mongolia in 2016, and found that Lineage 2 played an important role in recent outbreaks. Moreover, we found that Gansu province could play an important role in E30 spread and might be a possible origin site. Furthermore, Fujian, Shandong, Taiwan, and Zhejiang provinces also demonstrated significant involvement in E30 evolution and persistence over time in China. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12985-021-01590-4. BioMed Central 2021-06-06 /pmc/articles/PMC8182919/ /pubmed/34092258 http://dx.doi.org/10.1186/s12985-021-01590-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Tian, Xiaoling
Han, Zhenzhi
He, Yulong
Sun, Qiang
Wang, Wenrui
Xu, Wenbo
Li, Hongying
Zhang, Yong
Temporal phylogeny and molecular characterization of echovirus 30 associated with aseptic meningitis outbreaks in China
title Temporal phylogeny and molecular characterization of echovirus 30 associated with aseptic meningitis outbreaks in China
title_full Temporal phylogeny and molecular characterization of echovirus 30 associated with aseptic meningitis outbreaks in China
title_fullStr Temporal phylogeny and molecular characterization of echovirus 30 associated with aseptic meningitis outbreaks in China
title_full_unstemmed Temporal phylogeny and molecular characterization of echovirus 30 associated with aseptic meningitis outbreaks in China
title_short Temporal phylogeny and molecular characterization of echovirus 30 associated with aseptic meningitis outbreaks in China
title_sort temporal phylogeny and molecular characterization of echovirus 30 associated with aseptic meningitis outbreaks in china
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182919/
https://www.ncbi.nlm.nih.gov/pubmed/34092258
http://dx.doi.org/10.1186/s12985-021-01590-4
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