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Detecting hypoxia in vitro using (18)F-pretargeted IEDDA “click” chemistry in live cells

We have exemplified a pretargeted approach to interrogate hypoxia in live cells using radioactive bioorthogonal inverse electron demand Diels–Alder (IEDDA) “click” chemistry. Our novel (18)F-tetrazine probe ([(18)F]FB-Tz) and 2-nitroimidazole-based TCO targeting molecule (8) showed statistically sig...

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Detalles Bibliográficos
Autores principales:	Allott, Louis, Chen, Cen, Braga, Marta, Leung, Sau Fung Jacob, Wang, Ning, Barnes, Chris, Brickute, Diana, Carroll, Laurence, Aboagye, Eric O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182949/ https://www.ncbi.nlm.nih.gov/pubmed/34178309 http://dx.doi.org/10.1039/d1ra02482e

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