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Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units

OBJECTIVES: In Europe, there is a distinction between two different healthcare organisation systems, the tax-based healthcare system (THS) and the social health insurance system (SHI). Our aim was to investigate whether the characteristics, treatment and mortality of older, critically ill patients i...

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Autores principales: Wernly, Bernhard, Beil, Michael, Bruno, Raphael Romano, Binnebössel, Stephan, Kelm, Malte, Sigal, Sviri, van Heerden, Peter Vernon, Boumendil, Ariane, Artigas, Antonio, Cecconi, Maurizio, Marsh, Brian, Moreno, Rui, Oeyen, Sandra, Bollen Pinto, Bernardo, Szczeklik, Wojciech, Leaver, Susannah, Walther, Sten Mikael, Schefold, Joerg C, Joannidis, Michael, Fjølner, Jesper, Zafeiridis, Tilemachos, de Lange, Dylan, Guidet, Bertrand, Flaatten, Hans, Jung, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183284/
https://www.ncbi.nlm.nih.gov/pubmed/34083342
http://dx.doi.org/10.1136/bmjopen-2020-046909
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author Wernly, Bernhard
Beil, Michael
Bruno, Raphael Romano
Binnebössel, Stephan
Kelm, Malte
Sigal, Sviri
van Heerden, Peter Vernon
Boumendil, Ariane
Artigas, Antonio
Cecconi, Maurizio
Marsh, Brian
Moreno, Rui
Oeyen, Sandra
Bollen Pinto, Bernardo
Szczeklik, Wojciech
Leaver, Susannah
Walther, Sten Mikael
Schefold, Joerg C
Joannidis, Michael
Fjølner, Jesper
Zafeiridis, Tilemachos
de Lange, Dylan
Guidet, Bertrand
Flaatten, Hans
Jung, Christian
author_facet Wernly, Bernhard
Beil, Michael
Bruno, Raphael Romano
Binnebössel, Stephan
Kelm, Malte
Sigal, Sviri
van Heerden, Peter Vernon
Boumendil, Ariane
Artigas, Antonio
Cecconi, Maurizio
Marsh, Brian
Moreno, Rui
Oeyen, Sandra
Bollen Pinto, Bernardo
Szczeklik, Wojciech
Leaver, Susannah
Walther, Sten Mikael
Schefold, Joerg C
Joannidis, Michael
Fjølner, Jesper
Zafeiridis, Tilemachos
de Lange, Dylan
Guidet, Bertrand
Flaatten, Hans
Jung, Christian
author_sort Wernly, Bernhard
collection PubMed
description OBJECTIVES: In Europe, there is a distinction between two different healthcare organisation systems, the tax-based healthcare system (THS) and the social health insurance system (SHI). Our aim was to investigate whether the characteristics, treatment and mortality of older, critically ill patients in the intensive care unit (ICU) differed between THS and SHI. SETTING: ICUs in 16 European countries. PARTICIPANTS: In total, 7817 critically ill older (≥80 years) patients were included in this study, 4941 in THS and 2876 in the SHI systems. PRIMARY AND SECONDARY OUTCOMES MEASURES: We chose generalised estimation equations with robust standard errors to produce population average adjusted OR (aOR). We adjusted for patient-specific variables, health economic data, including gross domestic product (GDP) and human development index (HDI), and treatment strategies. RESULTS: In SHI systems, there were higher rates of frail patients (Clinical Frailty Scale>4; 46% vs 41%; p<0.001), longer length of ICU stays (90±162 vs 72±134 hours; p<0.001) and increased levels of organ support. The ICU mortality (aOR 1.50, 95% CI 1.09 to 2.06; p=0.01) was consistently higher in the SHI; however, the 30-day mortality (aOR 0.89, 95% CI 0.66 to 1.21; p=0.47) was similar between THS and SHI. In a sensitivity analysis stratifying for the health economic data, the 30-day mortality was higher in SHI, in low GDP per capita (aOR 2.17, 95% CI 1.42 to 3.58) and low HDI (aOR 1.22, 95% CI 1.64 to 2.20) settings. CONCLUSIONS: The 30-day mortality was similar in both systems. Patients in SHI were older, sicker and frailer at baseline, which could be interpreted as a sign for a more liberal admission policy in SHI. We believe that the observed trend towards ICU excess mortality in SHI results mainly from a more liberal admission policy and an increase in treatment limitations. TRIAL REGISTRATION NUMBERS: NCT03134807 and NCT03370692.
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spelling pubmed-81832842021-06-17 Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units Wernly, Bernhard Beil, Michael Bruno, Raphael Romano Binnebössel, Stephan Kelm, Malte Sigal, Sviri van Heerden, Peter Vernon Boumendil, Ariane Artigas, Antonio Cecconi, Maurizio Marsh, Brian Moreno, Rui Oeyen, Sandra Bollen Pinto, Bernardo Szczeklik, Wojciech Leaver, Susannah Walther, Sten Mikael Schefold, Joerg C Joannidis, Michael Fjølner, Jesper Zafeiridis, Tilemachos de Lange, Dylan Guidet, Bertrand Flaatten, Hans Jung, Christian BMJ Open Intensive Care OBJECTIVES: In Europe, there is a distinction between two different healthcare organisation systems, the tax-based healthcare system (THS) and the social health insurance system (SHI). Our aim was to investigate whether the characteristics, treatment and mortality of older, critically ill patients in the intensive care unit (ICU) differed between THS and SHI. SETTING: ICUs in 16 European countries. PARTICIPANTS: In total, 7817 critically ill older (≥80 years) patients were included in this study, 4941 in THS and 2876 in the SHI systems. PRIMARY AND SECONDARY OUTCOMES MEASURES: We chose generalised estimation equations with robust standard errors to produce population average adjusted OR (aOR). We adjusted for patient-specific variables, health economic data, including gross domestic product (GDP) and human development index (HDI), and treatment strategies. RESULTS: In SHI systems, there were higher rates of frail patients (Clinical Frailty Scale>4; 46% vs 41%; p<0.001), longer length of ICU stays (90±162 vs 72±134 hours; p<0.001) and increased levels of organ support. The ICU mortality (aOR 1.50, 95% CI 1.09 to 2.06; p=0.01) was consistently higher in the SHI; however, the 30-day mortality (aOR 0.89, 95% CI 0.66 to 1.21; p=0.47) was similar between THS and SHI. In a sensitivity analysis stratifying for the health economic data, the 30-day mortality was higher in SHI, in low GDP per capita (aOR 2.17, 95% CI 1.42 to 3.58) and low HDI (aOR 1.22, 95% CI 1.64 to 2.20) settings. CONCLUSIONS: The 30-day mortality was similar in both systems. Patients in SHI were older, sicker and frailer at baseline, which could be interpreted as a sign for a more liberal admission policy in SHI. We believe that the observed trend towards ICU excess mortality in SHI results mainly from a more liberal admission policy and an increase in treatment limitations. TRIAL REGISTRATION NUMBERS: NCT03134807 and NCT03370692. BMJ Publishing Group 2021-06-03 /pmc/articles/PMC8183284/ /pubmed/34083342 http://dx.doi.org/10.1136/bmjopen-2020-046909 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Intensive Care
Wernly, Bernhard
Beil, Michael
Bruno, Raphael Romano
Binnebössel, Stephan
Kelm, Malte
Sigal, Sviri
van Heerden, Peter Vernon
Boumendil, Ariane
Artigas, Antonio
Cecconi, Maurizio
Marsh, Brian
Moreno, Rui
Oeyen, Sandra
Bollen Pinto, Bernardo
Szczeklik, Wojciech
Leaver, Susannah
Walther, Sten Mikael
Schefold, Joerg C
Joannidis, Michael
Fjølner, Jesper
Zafeiridis, Tilemachos
de Lange, Dylan
Guidet, Bertrand
Flaatten, Hans
Jung, Christian
Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units
title Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units
title_full Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units
title_fullStr Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units
title_full_unstemmed Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units
title_short Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units
title_sort provision of critical care for the elderly in europe: a retrospective comparison of national healthcare frameworks in intensive care units
topic Intensive Care
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183284/
https://www.ncbi.nlm.nih.gov/pubmed/34083342
http://dx.doi.org/10.1136/bmjopen-2020-046909
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