Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2

The N‐Myc Downstream‐Regulated Gene 4 (NDRG4), a prominent biomarker for colorectal cancer (CRC), is specifically expressed by enteric neurons. Considering that nerves are important members of the tumor microenvironment, we here establish different Ndrg4 knockout (Ndrg4 (−/−)) CRC models and an indi...

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Detalles Bibliográficos
Autores principales: Vaes, Nathalie, Schonkeren, Simone L, Rademakers, Glenn, Holland, Amy M, Koch, Alexander, Gijbels, Marion J, Keulers, Tom G, de Wit, Meike, Moonen, Laura, Van der Meer, Jaleesa R M, van den Boezem, Edith, Wolfs, Tim G A M, Threadgill, David W, Demmers, Jeroen, Fijneman, Remond J A, Jimenez, Connie R, Vanden Berghe, Pieter, Smits, Kim M, Rouschop, Kasper M A, Boesmans, Werend, Hofstra, Robert M W, Melotte, Veerle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183412/
https://www.ncbi.nlm.nih.gov/pubmed/33890711
http://dx.doi.org/10.15252/embr.202051913

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