Interferon‐induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20

Hepatitis B virus (HBV) persists by depositing a covalently closed circular DNA (cccDNA) in the nucleus of infected cells that cannot be targeted by available antivirals. Interferons can diminish HBV cccDNA via APOBEC3‐mediated deamination. Here, we show that overexpression of APOBEC3A alone is not...

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Detalles Bibliográficos
Autores principales: Stadler, Daniela, Kächele, Martin, Jones, Alisha N, Hess, Julia, Urban, Christian, Schneider, Jessica, Xia, Yuchen, Oswald, Andreas, Nebioglu, Firat, Bester, Romina, Lasitschka, Felix, Ringelhan, Marc, Ko, Chunkyu, Chou, Wen‐Min, Geerlof, Arie, van de Klundert, Maarten A, Wettengel, Jochen M, Schirmacher, Peter, Heikenwälder, Mathias, Schreiner, Sabrina, Bartenschlager, Ralf, Pichlmair, Andreas, Sattler, Michael, Unger, Kristian, Protzer, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183418/
https://www.ncbi.nlm.nih.gov/pubmed/33969602
http://dx.doi.org/10.15252/embr.201949568

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