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FCGR Genetic Variation in Two Populations From Ecuador Highlands—Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene

Fcγ receptors (FcγR), cell-surface glycoproteins that bind antigen-IgG complexes, control both humoral and cellular immune responses. The FCGR locus on chromosome 1q23.3 comprises five homologous genes encoding low-affinity FcγRII and FcγRIII, and displays functionally relevant polymorphism that imp...

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Detalles Bibliográficos
Autores principales:	Moraru, Manuela, Perez-Portilla, Adriana, Al-Akioui Sanz, Karima, Blazquez-Moreno, Alfonso, Arnaiz-Villena, Antonio, Reyburn, Hugh T., Vilches, Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183472/ https://www.ncbi.nlm.nih.gov/pubmed/34108956 http://dx.doi.org/10.3389/fimmu.2021.615645

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