Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension

Pathologies of the micro- and macrovascular systems are a hallmark of the metabolic syndrome, which can lead to chronically elevated blood pressure. However, the underlying pathomechanisms involved still need to be clarified. Here, we report that an obesity-associated increase in serum leptin trigge...

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Detalles Bibliográficos
Autores principales: Gruber, Tim, Pan, Chenchen, Contreras, Raian E., Wiedemann, Tobias, Morgan, Donald A., Skowronski, Alicja A., Lefort, Sandrine, De Bernardis Murat, Cahuê, Le Thuc, Ophelia, Legutko, Beata, Ruiz-Ojeda, Francisco J., Fuente-Fernández, María de la, García-Villalón, Angel Luis, González-Hedström, Daniel, Huber, Melanie, Szigeti-Buck, Klara, Müller, Timo D., Ussar, Siegfried, Pfluger, Paul, Woods, Steve C., Ertürk, Ali, LeDuc, Charles A., Rahmouni, Kamal, Granado, Miriam, Horvath, Tamas L., Tschöp, Matthias H., García-Cáceres, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183500/
https://www.ncbi.nlm.nih.gov/pubmed/33951475
http://dx.doi.org/10.1016/j.cmet.2021.04.007

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