Mitochondrial metabolism promotes adaptation to proteotoxic stress

The mechanisms by which cells adapt to proteotoxic stress are largely unknown, but key to understanding how tumor cells, particularly in vivo, are largely resistant to proteasome inhibitors. Analysis of cancer cell lines, mouse xenografts and patient-derived tumor samples all showed an association b...

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Detalles Bibliográficos
Autores principales: Tsvetkov, Peter, Detappe, Alexandre, Cai, Kai, Keys, Heather R., Brune, Zarina, Ying, Weiwen, Thiru, Prathapan, Reidy, Mairead, Kugener, Guillaume, Rossen, Jordan, Kocak, Mustafa, Kory, Nora, Tsherniak, Aviad, Santagata, Sandro, Whitesell, Luke, Ghobrial, Irene M., Markley, John L., Lindquist, Susan, Golub, Todd R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183600/
https://www.ncbi.nlm.nih.gov/pubmed/31133756
http://dx.doi.org/10.1038/s41589-019-0291-9

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