Co-inhibition of SMAD and MAPK signaling enhances (124)I uptake in BRAF-mutant thyroid cancers

Constitutive MAPK activation silences genes required for iodide uptake and thyroid hormone biosynthesis in thyroid follicular cells. Accordingly, most BRAF(V600E) papillary thyroid cancers (PTC) are refractory to radioiodide (RAI) therapy. MAPK pathway inhibitors rescue thyroid-differentiated proper...

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Detalles Bibliográficos
Autores principales: Luckett, Kathleen A, Cracchiolo, Jennifer R, Krishnamoorthy, Gnana P, Leandro-Garcia, Luis Javier, Nagarajah, James, Saqcena, Mahesh, Lester, Rona, Im, Soo Y, Zhao, Zhen, Lowe, Scott W, de Stanchina, Elisa, Sherman, Eric J, Ho, Alan L, Leach, Steven D, Knauf, Jeffrey A, Fagin, James A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183640/
https://www.ncbi.nlm.nih.gov/pubmed/33890869
http://dx.doi.org/10.1530/ERC-21-0017

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