Case Report: A Severe and Multi-Site Nocardia farcinica Infection Rapidly and Precisely Identified by Metagenomic Next-Generation Sequencing

Nocardia genus is an aerobic, gram-positive, and opportunistic pathogen, which mainly affects cell-mediated immunosuppressed patients. Early diagnosis and treatment greatly improve prognosis. However, the limitation of golden standard-bacterial culture exists. Here, we report a 61-year-old male with...

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Autores principales: Jiao, Mengfan, Deng, Xiang, Yang, Hongfu, Dong, Junqiang, Lv, Jun, Li, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183679/
https://www.ncbi.nlm.nih.gov/pubmed/34109198
http://dx.doi.org/10.3389/fmed.2021.669552
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author Jiao, Mengfan
Deng, Xiang
Yang, Hongfu
Dong, Junqiang
Lv, Jun
Li, Fang
author_facet Jiao, Mengfan
Deng, Xiang
Yang, Hongfu
Dong, Junqiang
Lv, Jun
Li, Fang
author_sort Jiao, Mengfan
collection PubMed
description Nocardia genus is an aerobic, gram-positive, and opportunistic pathogen, which mainly affects cell-mediated immunosuppressed patients. Early diagnosis and treatment greatly improve prognosis. However, the limitation of golden standard-bacterial culture exists. Here, we report a 61-year-old male with pneumonia, sepsis and intermuscular abscesses induced by Nocardia farcinica. Venous blood culture reported negative results. Former improper diagnosis and treatment did not improve his condition. With the assistant of metagenomic next-generation sequencing, the pathogen was identified as Nocardia farcinica. He was then applied with accurate treatment and had a remarkable clinical and radiological improvement.
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spelling pubmed-81836792021-06-08 Case Report: A Severe and Multi-Site Nocardia farcinica Infection Rapidly and Precisely Identified by Metagenomic Next-Generation Sequencing Jiao, Mengfan Deng, Xiang Yang, Hongfu Dong, Junqiang Lv, Jun Li, Fang Front Med (Lausanne) Medicine Nocardia genus is an aerobic, gram-positive, and opportunistic pathogen, which mainly affects cell-mediated immunosuppressed patients. Early diagnosis and treatment greatly improve prognosis. However, the limitation of golden standard-bacterial culture exists. Here, we report a 61-year-old male with pneumonia, sepsis and intermuscular abscesses induced by Nocardia farcinica. Venous blood culture reported negative results. Former improper diagnosis and treatment did not improve his condition. With the assistant of metagenomic next-generation sequencing, the pathogen was identified as Nocardia farcinica. He was then applied with accurate treatment and had a remarkable clinical and radiological improvement. Frontiers Media S.A. 2021-05-24 /pmc/articles/PMC8183679/ /pubmed/34109198 http://dx.doi.org/10.3389/fmed.2021.669552 Text en Copyright © 2021 Jiao, Deng, Yang, Dong, Lv and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Jiao, Mengfan
Deng, Xiang
Yang, Hongfu
Dong, Junqiang
Lv, Jun
Li, Fang
Case Report: A Severe and Multi-Site Nocardia farcinica Infection Rapidly and Precisely Identified by Metagenomic Next-Generation Sequencing
title Case Report: A Severe and Multi-Site Nocardia farcinica Infection Rapidly and Precisely Identified by Metagenomic Next-Generation Sequencing
title_full Case Report: A Severe and Multi-Site Nocardia farcinica Infection Rapidly and Precisely Identified by Metagenomic Next-Generation Sequencing
title_fullStr Case Report: A Severe and Multi-Site Nocardia farcinica Infection Rapidly and Precisely Identified by Metagenomic Next-Generation Sequencing
title_full_unstemmed Case Report: A Severe and Multi-Site Nocardia farcinica Infection Rapidly and Precisely Identified by Metagenomic Next-Generation Sequencing
title_short Case Report: A Severe and Multi-Site Nocardia farcinica Infection Rapidly and Precisely Identified by Metagenomic Next-Generation Sequencing
title_sort case report: a severe and multi-site nocardia farcinica infection rapidly and precisely identified by metagenomic next-generation sequencing
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183679/
https://www.ncbi.nlm.nih.gov/pubmed/34109198
http://dx.doi.org/10.3389/fmed.2021.669552
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