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Immune thrombocytopenia associated with Hashimoto thyroiditis in a pediatric patient: A case report
RATIONALE: Immune thrombocytopenia (ITP) is one of the most commonly acquired bleeding diseases in children. Infection and autoimmune disorders are the most common causes of ITP. The pathogenic mechanism of ITP is complex and is not completely understood. Understanding the underlying causes or disor...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183690/ https://www.ncbi.nlm.nih.gov/pubmed/34087867 http://dx.doi.org/10.1097/MD.0000000000026140 |
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author | Tian, Zhiqing Gao, Hu Xiao, Dongqiong Li, Xihong |
author_facet | Tian, Zhiqing Gao, Hu Xiao, Dongqiong Li, Xihong |
author_sort | Tian, Zhiqing |
collection | PubMed |
description | RATIONALE: Immune thrombocytopenia (ITP) is one of the most commonly acquired bleeding diseases in children. Infection and autoimmune disorders are the most common causes of ITP. The pathogenic mechanism of ITP is complex and is not completely understood. Understanding the underlying causes or disorders of ITP will improve the prognosis and make therapy more targeted. PATIENT CONCERNS: An 8-year-old girl with ITP responded poorly to first- and second-line treatment. The patient showed multiple scattered petechiae, ecchymoses, and purpura in the skin and blood clots in the oral mucous membrane. DIAGNOSES: The patient was diagnosed with ITP associated with Hashimoto thyroiditis. INTERVENTIONS: The patient was admitted to our emergency department and received platelet transfusion, IVIG, glucocorticoids and eltrombopag. The patient's thrombocytopenia resolved within 18 days after the administration of levothyroxine treatment. OUTCOMES: The patient was diagnosed with Hashimoto thyroiditis, and the platelet count recovered on the 3rd day of levothyroxine treatment. The platelet count became steadily normal with levothyroxine and prednisone treatment within 2 months of follow-up. LESSONS: Early identification of the underlying reasons and treatment with multiple modalities may be useful in improving the prognosis of ITP. The treatment of thyroid disease and restoration of the euthyroid state impact the clinical outcome of ITP in children. |
format | Online Article Text |
id | pubmed-8183690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-81836902021-06-07 Immune thrombocytopenia associated with Hashimoto thyroiditis in a pediatric patient: A case report Tian, Zhiqing Gao, Hu Xiao, Dongqiong Li, Xihong Medicine (Baltimore) 4800 RATIONALE: Immune thrombocytopenia (ITP) is one of the most commonly acquired bleeding diseases in children. Infection and autoimmune disorders are the most common causes of ITP. The pathogenic mechanism of ITP is complex and is not completely understood. Understanding the underlying causes or disorders of ITP will improve the prognosis and make therapy more targeted. PATIENT CONCERNS: An 8-year-old girl with ITP responded poorly to first- and second-line treatment. The patient showed multiple scattered petechiae, ecchymoses, and purpura in the skin and blood clots in the oral mucous membrane. DIAGNOSES: The patient was diagnosed with ITP associated with Hashimoto thyroiditis. INTERVENTIONS: The patient was admitted to our emergency department and received platelet transfusion, IVIG, glucocorticoids and eltrombopag. The patient's thrombocytopenia resolved within 18 days after the administration of levothyroxine treatment. OUTCOMES: The patient was diagnosed with Hashimoto thyroiditis, and the platelet count recovered on the 3rd day of levothyroxine treatment. The platelet count became steadily normal with levothyroxine and prednisone treatment within 2 months of follow-up. LESSONS: Early identification of the underlying reasons and treatment with multiple modalities may be useful in improving the prognosis of ITP. The treatment of thyroid disease and restoration of the euthyroid state impact the clinical outcome of ITP in children. Lippincott Williams & Wilkins 2021-06-04 /pmc/articles/PMC8183690/ /pubmed/34087867 http://dx.doi.org/10.1097/MD.0000000000026140 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | 4800 Tian, Zhiqing Gao, Hu Xiao, Dongqiong Li, Xihong Immune thrombocytopenia associated with Hashimoto thyroiditis in a pediatric patient: A case report |
title | Immune thrombocytopenia associated with Hashimoto thyroiditis in a pediatric patient: A case report |
title_full | Immune thrombocytopenia associated with Hashimoto thyroiditis in a pediatric patient: A case report |
title_fullStr | Immune thrombocytopenia associated with Hashimoto thyroiditis in a pediatric patient: A case report |
title_full_unstemmed | Immune thrombocytopenia associated with Hashimoto thyroiditis in a pediatric patient: A case report |
title_short | Immune thrombocytopenia associated with Hashimoto thyroiditis in a pediatric patient: A case report |
title_sort | immune thrombocytopenia associated with hashimoto thyroiditis in a pediatric patient: a case report |
topic | 4800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183690/ https://www.ncbi.nlm.nih.gov/pubmed/34087867 http://dx.doi.org/10.1097/MD.0000000000026140 |
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