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Ex Situ Perfusion of Hearts Donated After Euthanasia: A Promising Contribution to Heart Transplantation
Organ donation after euthanasia is performed in an increasing number of countries. In this donation after circulatory death procedure, it has not been possible to donate the heart. Recent literature, however, reports positive results of heart donation after circulatory death. Therefore, patients who...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183709/ https://www.ncbi.nlm.nih.gov/pubmed/34104712 http://dx.doi.org/10.1097/TXD.0000000000001120 |
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author | van Suylen, Vincent Bunnik, Eline M. Hagenaars, Johanna A.M. Ertugrul, Imran A. Bollen, Jan A.M. Mariani, Massimo A. Erasmus, Michiel E. |
author_facet | van Suylen, Vincent Bunnik, Eline M. Hagenaars, Johanna A.M. Ertugrul, Imran A. Bollen, Jan A.M. Mariani, Massimo A. Erasmus, Michiel E. |
author_sort | van Suylen, Vincent |
collection | PubMed |
description | Organ donation after euthanasia is performed in an increasing number of countries. In this donation after circulatory death procedure, it has not been possible to donate the heart. Recent literature, however, reports positive results of heart donation after circulatory death. Therefore, patients who donate organs following euthanasia might be suitable candidates for heart donation. We want to confirm this assumption by sharing the results of 2 cases of heart donation following euthanasia with ex situ subnormothermic heart preservation. Our aim is to raise awareness of the potential of heart donation following euthanasia for both clinical transplantation and research. METHODS. The data of 2 consecutive heart donations following euthanasia were collected prospectively. Informed consent was obtained from the patients themselves for heart donation for research purposes. An acellular oxygenated subnormothermic machine perfusion strategy was used to preserve both donor hearts. Subsequently, the hearts were evaluated on a normothermic perfusion machine using a balloon in the left ventricle. RESULTS. Heart donation following euthanasia was feasible without significant changes in existing retrieval protocols. Duration of machine perfusion preservation was 408 and 432 minutes, for heart 1 and 2, respectively. For heart 1, developed pressure (P(dev)) was 119 mm Hg, maximal rate of pressure rise (dP/dt(max)), and fall (dP/dt(min)) were 1524 mm Hg/s and −1057 mm Hg/s, respectively. For heart 2, P(dev) was 142 mm Hg, dP/dt(max) was 1098 mm Hg/s, and dP/dt(min) was −802 mm Hg/s. CONCLUSIONS. Hearts donated following euthanasia are highly valuable for research purposes and can have sufficient quality to be transplanted. With the implementation of ex situ heart perfusion, patients who are to donate their organs following euthanasia should also be able to donate their hearts. The complex combination of euthanasia and heart donation is ethically sound and surgically feasible and can contribute to shortening the heart transplant waiting list. |
format | Online Article Text |
id | pubmed-8183709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-81837092021-06-07 Ex Situ Perfusion of Hearts Donated After Euthanasia: A Promising Contribution to Heart Transplantation van Suylen, Vincent Bunnik, Eline M. Hagenaars, Johanna A.M. Ertugrul, Imran A. Bollen, Jan A.M. Mariani, Massimo A. Erasmus, Michiel E. Transplant Direct Heart Transplantation Organ donation after euthanasia is performed in an increasing number of countries. In this donation after circulatory death procedure, it has not been possible to donate the heart. Recent literature, however, reports positive results of heart donation after circulatory death. Therefore, patients who donate organs following euthanasia might be suitable candidates for heart donation. We want to confirm this assumption by sharing the results of 2 cases of heart donation following euthanasia with ex situ subnormothermic heart preservation. Our aim is to raise awareness of the potential of heart donation following euthanasia for both clinical transplantation and research. METHODS. The data of 2 consecutive heart donations following euthanasia were collected prospectively. Informed consent was obtained from the patients themselves for heart donation for research purposes. An acellular oxygenated subnormothermic machine perfusion strategy was used to preserve both donor hearts. Subsequently, the hearts were evaluated on a normothermic perfusion machine using a balloon in the left ventricle. RESULTS. Heart donation following euthanasia was feasible without significant changes in existing retrieval protocols. Duration of machine perfusion preservation was 408 and 432 minutes, for heart 1 and 2, respectively. For heart 1, developed pressure (P(dev)) was 119 mm Hg, maximal rate of pressure rise (dP/dt(max)), and fall (dP/dt(min)) were 1524 mm Hg/s and −1057 mm Hg/s, respectively. For heart 2, P(dev) was 142 mm Hg, dP/dt(max) was 1098 mm Hg/s, and dP/dt(min) was −802 mm Hg/s. CONCLUSIONS. Hearts donated following euthanasia are highly valuable for research purposes and can have sufficient quality to be transplanted. With the implementation of ex situ heart perfusion, patients who are to donate their organs following euthanasia should also be able to donate their hearts. The complex combination of euthanasia and heart donation is ethically sound and surgically feasible and can contribute to shortening the heart transplant waiting list. Lippincott Williams & Wilkins 2021-02-22 /pmc/articles/PMC8183709/ /pubmed/34104712 http://dx.doi.org/10.1097/TXD.0000000000001120 Text en Copyright © 2021 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Heart Transplantation van Suylen, Vincent Bunnik, Eline M. Hagenaars, Johanna A.M. Ertugrul, Imran A. Bollen, Jan A.M. Mariani, Massimo A. Erasmus, Michiel E. Ex Situ Perfusion of Hearts Donated After Euthanasia: A Promising Contribution to Heart Transplantation |
title | Ex Situ Perfusion of Hearts Donated After Euthanasia: A Promising Contribution to Heart Transplantation |
title_full | Ex Situ Perfusion of Hearts Donated After Euthanasia: A Promising Contribution to Heart Transplantation |
title_fullStr | Ex Situ Perfusion of Hearts Donated After Euthanasia: A Promising Contribution to Heart Transplantation |
title_full_unstemmed | Ex Situ Perfusion of Hearts Donated After Euthanasia: A Promising Contribution to Heart Transplantation |
title_short | Ex Situ Perfusion of Hearts Donated After Euthanasia: A Promising Contribution to Heart Transplantation |
title_sort | ex situ perfusion of hearts donated after euthanasia: a promising contribution to heart transplantation |
topic | Heart Transplantation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183709/ https://www.ncbi.nlm.nih.gov/pubmed/34104712 http://dx.doi.org/10.1097/TXD.0000000000001120 |
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