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What clinical trials of ablation for atrial fibrillation tell us – and what they do not

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in clinical practice. Radiofrequency and cryoballoon catheter ablation are therapeutic options in addition to antiarrhythmic drug therapy for the treatment of AF. Ablation is effective at reducing recurrent atrial arrhythmias and also...

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Detalles Bibliográficos
Autores principales: Amuthan, Ram, Curtis, Anne B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183809/
https://www.ncbi.nlm.nih.gov/pubmed/34113920
http://dx.doi.org/10.1016/j.hroo.2021.02.001
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author Amuthan, Ram
Curtis, Anne B.
author_facet Amuthan, Ram
Curtis, Anne B.
author_sort Amuthan, Ram
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description Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in clinical practice. Radiofrequency and cryoballoon catheter ablation are therapeutic options in addition to antiarrhythmic drug therapy for the treatment of AF. Ablation is effective at reducing recurrent atrial arrhythmias and also in the reduction of AF burden. Besides arrhythmia control, improvement in quality of life and clinical outcomes are also desirable goals with AF treatment. Randomized clinical trials have evaluated ablation in several patient populations, including symptomatic patients as first-line or second-line therapy, asymptomatic patients, and patients with heart failure. These trials clarify the durability of ablation in arrhythmia control, clarify quality-of-life improvement, and identify patient populations in whom ablation may be expected to improve clinical outcomes. In this review, we summarize the major clinical trials involving ablation; discuss the strengths, weakness, and clinical implications of these trials; and highlight the knowledge gaps in our current understanding of AF ablation for future clinical studies.
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spelling pubmed-81838092021-06-09 What clinical trials of ablation for atrial fibrillation tell us – and what they do not Amuthan, Ram Curtis, Anne B. Heart Rhythm O2 Topics in Review Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in clinical practice. Radiofrequency and cryoballoon catheter ablation are therapeutic options in addition to antiarrhythmic drug therapy for the treatment of AF. Ablation is effective at reducing recurrent atrial arrhythmias and also in the reduction of AF burden. Besides arrhythmia control, improvement in quality of life and clinical outcomes are also desirable goals with AF treatment. Randomized clinical trials have evaluated ablation in several patient populations, including symptomatic patients as first-line or second-line therapy, asymptomatic patients, and patients with heart failure. These trials clarify the durability of ablation in arrhythmia control, clarify quality-of-life improvement, and identify patient populations in whom ablation may be expected to improve clinical outcomes. In this review, we summarize the major clinical trials involving ablation; discuss the strengths, weakness, and clinical implications of these trials; and highlight the knowledge gaps in our current understanding of AF ablation for future clinical studies. Elsevier 2021-02-16 /pmc/articles/PMC8183809/ /pubmed/34113920 http://dx.doi.org/10.1016/j.hroo.2021.02.001 Text en © 2021 Heart Rhythm Society. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Topics in Review
Amuthan, Ram
Curtis, Anne B.
What clinical trials of ablation for atrial fibrillation tell us – and what they do not
title What clinical trials of ablation for atrial fibrillation tell us – and what they do not
title_full What clinical trials of ablation for atrial fibrillation tell us – and what they do not
title_fullStr What clinical trials of ablation for atrial fibrillation tell us – and what they do not
title_full_unstemmed What clinical trials of ablation for atrial fibrillation tell us – and what they do not
title_short What clinical trials of ablation for atrial fibrillation tell us – and what they do not
title_sort what clinical trials of ablation for atrial fibrillation tell us – and what they do not
topic Topics in Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183809/
https://www.ncbi.nlm.nih.gov/pubmed/34113920
http://dx.doi.org/10.1016/j.hroo.2021.02.001
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