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Serum potassium levels and prognosis in HBV‐associated decompensated cirrhosis
BACKGROUND: Serum potassium disorders are commonly seen in patients with advanced cirrhosis and have a detrimental effect on clinical outcome, but its role in HBV‐related decompensated cirrhosis (DeCi) is remained to be illustrated. We aim to assess the effects of serum potassium on outcomes in HBV‐...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183925/ https://www.ncbi.nlm.nih.gov/pubmed/33951234 http://dx.doi.org/10.1002/jcla.23775 |
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author | Huang, JianJiang Cai, Ming He, Xia |
author_facet | Huang, JianJiang Cai, Ming He, Xia |
author_sort | Huang, JianJiang |
collection | PubMed |
description | BACKGROUND: Serum potassium disorders are commonly seen in patients with advanced cirrhosis and have a detrimental effect on clinical outcome, but its role in HBV‐related decompensated cirrhosis (DeCi) is remained to be illustrated. We aim to assess the effects of serum potassium on outcomes in HBV‐DeCi patients. METHODS: Retrospective study included 155 subjects. Multivariate analysis was used to determine the independent prognostic factor. Predictive ability of mortality for variables was determined using the receiver operating characteristics curves. RESULTS: The 30‐day in‐hospital mortality was 12.9%. Serum potassium levels differed markedly between survivors and non‐survivors. On multivariate analysis, Model for End‐Stage Liver Disease (MELD) score and serum potassium level were identified as independent predictors of outcomes in HBV‐DeCi patients. The combination of serum potassium and MELD score could improve prognostic accuracy in these patients. CONCLUSIONS: Our findings suggest that serum potassium is an effective predictor for poor outcomes in HBV‐DeCi patients. |
format | Online Article Text |
id | pubmed-8183925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81839252021-06-16 Serum potassium levels and prognosis in HBV‐associated decompensated cirrhosis Huang, JianJiang Cai, Ming He, Xia J Clin Lab Anal Research Articles BACKGROUND: Serum potassium disorders are commonly seen in patients with advanced cirrhosis and have a detrimental effect on clinical outcome, but its role in HBV‐related decompensated cirrhosis (DeCi) is remained to be illustrated. We aim to assess the effects of serum potassium on outcomes in HBV‐DeCi patients. METHODS: Retrospective study included 155 subjects. Multivariate analysis was used to determine the independent prognostic factor. Predictive ability of mortality for variables was determined using the receiver operating characteristics curves. RESULTS: The 30‐day in‐hospital mortality was 12.9%. Serum potassium levels differed markedly between survivors and non‐survivors. On multivariate analysis, Model for End‐Stage Liver Disease (MELD) score and serum potassium level were identified as independent predictors of outcomes in HBV‐DeCi patients. The combination of serum potassium and MELD score could improve prognostic accuracy in these patients. CONCLUSIONS: Our findings suggest that serum potassium is an effective predictor for poor outcomes in HBV‐DeCi patients. John Wiley and Sons Inc. 2021-05-05 /pmc/articles/PMC8183925/ /pubmed/33951234 http://dx.doi.org/10.1002/jcla.23775 Text en © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Huang, JianJiang Cai, Ming He, Xia Serum potassium levels and prognosis in HBV‐associated decompensated cirrhosis |
title | Serum potassium levels and prognosis in HBV‐associated decompensated cirrhosis |
title_full | Serum potassium levels and prognosis in HBV‐associated decompensated cirrhosis |
title_fullStr | Serum potassium levels and prognosis in HBV‐associated decompensated cirrhosis |
title_full_unstemmed | Serum potassium levels and prognosis in HBV‐associated decompensated cirrhosis |
title_short | Serum potassium levels and prognosis in HBV‐associated decompensated cirrhosis |
title_sort | serum potassium levels and prognosis in hbv‐associated decompensated cirrhosis |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183925/ https://www.ncbi.nlm.nih.gov/pubmed/33951234 http://dx.doi.org/10.1002/jcla.23775 |
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