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Serum potassium levels and prognosis in HBV‐associated decompensated cirrhosis

BACKGROUND: Serum potassium disorders are commonly seen in patients with advanced cirrhosis and have a detrimental effect on clinical outcome, but its role in HBV‐related decompensated cirrhosis (DeCi) is remained to be illustrated. We aim to assess the effects of serum potassium on outcomes in HBV‐...

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Detalles Bibliográficos
Autores principales: Huang, JianJiang, Cai, Ming, He, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183925/
https://www.ncbi.nlm.nih.gov/pubmed/33951234
http://dx.doi.org/10.1002/jcla.23775
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author Huang, JianJiang
Cai, Ming
He, Xia
author_facet Huang, JianJiang
Cai, Ming
He, Xia
author_sort Huang, JianJiang
collection PubMed
description BACKGROUND: Serum potassium disorders are commonly seen in patients with advanced cirrhosis and have a detrimental effect on clinical outcome, but its role in HBV‐related decompensated cirrhosis (DeCi) is remained to be illustrated. We aim to assess the effects of serum potassium on outcomes in HBV‐DeCi patients. METHODS: Retrospective study included 155 subjects. Multivariate analysis was used to determine the independent prognostic factor. Predictive ability of mortality for variables was determined using the receiver operating characteristics curves. RESULTS: The 30‐day in‐hospital mortality was 12.9%. Serum potassium levels differed markedly between survivors and non‐survivors. On multivariate analysis, Model for End‐Stage Liver Disease (MELD) score and serum potassium level were identified as independent predictors of outcomes in HBV‐DeCi patients. The combination of serum potassium and MELD score could improve prognostic accuracy in these patients. CONCLUSIONS: Our findings suggest that serum potassium is an effective predictor for poor outcomes in HBV‐DeCi patients.
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spelling pubmed-81839252021-06-16 Serum potassium levels and prognosis in HBV‐associated decompensated cirrhosis Huang, JianJiang Cai, Ming He, Xia J Clin Lab Anal Research Articles BACKGROUND: Serum potassium disorders are commonly seen in patients with advanced cirrhosis and have a detrimental effect on clinical outcome, but its role in HBV‐related decompensated cirrhosis (DeCi) is remained to be illustrated. We aim to assess the effects of serum potassium on outcomes in HBV‐DeCi patients. METHODS: Retrospective study included 155 subjects. Multivariate analysis was used to determine the independent prognostic factor. Predictive ability of mortality for variables was determined using the receiver operating characteristics curves. RESULTS: The 30‐day in‐hospital mortality was 12.9%. Serum potassium levels differed markedly between survivors and non‐survivors. On multivariate analysis, Model for End‐Stage Liver Disease (MELD) score and serum potassium level were identified as independent predictors of outcomes in HBV‐DeCi patients. The combination of serum potassium and MELD score could improve prognostic accuracy in these patients. CONCLUSIONS: Our findings suggest that serum potassium is an effective predictor for poor outcomes in HBV‐DeCi patients. John Wiley and Sons Inc. 2021-05-05 /pmc/articles/PMC8183925/ /pubmed/33951234 http://dx.doi.org/10.1002/jcla.23775 Text en © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Huang, JianJiang
Cai, Ming
He, Xia
Serum potassium levels and prognosis in HBV‐associated decompensated cirrhosis
title Serum potassium levels and prognosis in HBV‐associated decompensated cirrhosis
title_full Serum potassium levels and prognosis in HBV‐associated decompensated cirrhosis
title_fullStr Serum potassium levels and prognosis in HBV‐associated decompensated cirrhosis
title_full_unstemmed Serum potassium levels and prognosis in HBV‐associated decompensated cirrhosis
title_short Serum potassium levels and prognosis in HBV‐associated decompensated cirrhosis
title_sort serum potassium levels and prognosis in hbv‐associated decompensated cirrhosis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183925/
https://www.ncbi.nlm.nih.gov/pubmed/33951234
http://dx.doi.org/10.1002/jcla.23775
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